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Stroke, Vol 24, 310-313, Copyright © 1993 by American Heart Association

ARTICLES

Possible association of ischemic stroke with phentermine

J Kokkinos and SR Levine
Department of Neurology, Henry Ford Hospital and Health Sciences Center, Detroit, MI 48202-2689.

BACKGROUND AND PURPOSE: Some commonly used anorexiants, including methamphetamine and phenylpropanolamine, have been associated with stroke. Because phentermine is an anorexiant with a chemical structure similar to that of amphetamines, similar side effects might be expected. CASE DESCRIPTIONS: Two patients using phentermine (one was also using phendimetrazine) developed ischemic cerebrovascular disease. One suffered a cerebral infarct with angiographic evidence of vasculopathy involving multiple vascular beds. The other patient developed headache and a hemisensory disturbance of 7 days' duration. CONCLUSIONS: Phentermine, and possibly phendimetrazine, should be considered an anorexiant and sympathomimetic drug that can be associated with ischemic cerebrovascular disease.

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