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Stroke, Vol 24, 527-531, Copyright © 1993 by American Heart Association
BACKGROUND AND PURPOSE: Very few studies have addressed the identification
of prognostic factors in patients with a transient ischemic attack or minor
stroke. METHODS: We prospectively studied the prognostic value of clinical,
laboratory, radiological, and electrocardiographic findings in 997 patients
with a transient ischemic attack and 2,130 patients with a minor stroke who
were entered into a multicenter clinical trial. The mean follow-up period
was 2.6 years. RESULTS: A total of 302 patients died (212 from a vascular
cause), 272 had a stroke, and 200 had a cardiac event. By means of a
multivariate analysis we identified the following independent risk factors
for stroke, myocardial infarction, or vascular death: age of > 65 years;
male sex; dysarthria; multiple attacks; diabetes; angina pectoris;
intermittent claudication; computed tomographic evidence of any cerebral
infarct, especially a border zone infarct or white matter hypodensity; and
electrocardiographic evidence of an anteroseptal infarct, ST depression,
left ventricular hypertrophy, or left atrial conduction delay. Protective
predictors were monocular attacks only or the presence of rotatory
dizziness. CONCLUSION: A limited number of easily obtainable
characteristics are powerful predictors of major vascular events in
patients with cerebral ischemia.
ARTICLES
Predictors of major vascular events in patients with a transient ischemic attack or nondisabling stroke. The Dutch TIA Trial Study Group
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