This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rich, C. Articles by Konkol, R. J. Search for Related Content PubMed PubMed Citation Articles by Rich, C. Articles by Konkol, R. J.

Stroke, Vol 24, 603-605, Copyright © 1993 by American Heart Association

ARTICLES

An unusual cause of cerebral venous thrombosis in a four-year-old child

C Rich, JC Gill, S Wernick and RJ Konkol
Department of Neurology, Medical College of Wisconsin, Milwaukee.

BACKGROUND AND PURPOSE: Inherited protein S deficiency has been associated with an increased risk of thromboembolic disease. It is possible that such a coagulopathy could predispose children to the development of strokes by permitting clot formation in response to stimuli that ordinarily would be insufficient to cause thrombus formation. CASE DESCRIPTION: We evaluated a previously well 4-year-old boy who developed cerebral venous thrombosis after suffering minor head trauma. Crossed-immunoelectrophoresis of his plasma showed a marked decrease of the free, active form of protein S. Family studies revealed that the patient's father and other paternal relatives had a similar abnormality of protein S. CONCLUSIONS: We suggest that the cerebral venous thrombosis in this child was initially precipitated by minor head trauma and pathological thrombus formation was then potentiated by inherited protein S deficiency. This case extends the clinical spectrum for protein S deficiency and emphasizes the importance of evaluating family members to establish a specific diagnosis and therapeutic intervention.

This article has been cited by other articles:

				P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A. D. Michelson Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 645S - 687S. [Abstract] [Full Text] [PDF]

				G. deVeber, M. Andrew, C. Adams, B. Bjornson, F. Booth, D. J. Buckley, C. S. Camfield, M. David, P. Humphreys, P. Langevin, et al. Cerebral Sinovenous Thrombosis in Children N. Engl. J. Med., August 9, 2001; 345(6): 417 - 423. [Abstract] [Full Text] [PDF]

				G. deVeber, P. Monagle, A. Chan, D. MacGregor, R. Curtis, S. Lee, P. Vegh, M. Adams, V. Marzinotto, M. Leaker, et al. Prothrombotic Disorders in Infants and Children With Cerebral Thromboembolism Arch Neurol, December 1, 1998; 55(12): 1539 - 1543. [Abstract] [Full Text] [PDF]

				Y. Mira, S. Mendizabal, A. Vaya, N. Sanchis, P. Villa, and J. Aznar Sinus Venous Thrombosis Associated with a Nephrotic Syndrome in an Eight-Year-Old Child Clinical and Applied Thrombosis/Hemostasis, April 1, 1996; 2(2): 142 - 144. [Abstract] [PDF]