Stroke, Vol 24, 779-786, Copyright © 1993 by American Heart Association
SY Leung, TH Ng, ST Yuen, IJ Lauder and FC Ho
BACKGROUND AND PURPOSE: The clinical pattern of stroke and the angiographic
distribution of cerebral atherosclerosis in Chinese are different from
those in Caucasians. Pathological data from autopsy studies are lacking.
METHODS: The intracranial and extracranial arteries supplying the brains of
114 consecutive Chinese patients undergoing autopsy in a regional general
hospital were examined by computer-assisted morphometric analysis under a
microscope as well as by macroscopic grading for atherosclerotic narrowing.
The severity was correlated with various atherosclerosis-related factors.
RESULTS: Atherosclerosis of the intracranial cerebral vessels was more
severe than that of the extracranial vessels. The distal branches of the
intracranial vessels were also commonly involved. Hypertension and diabetes
mellitus were identified as factors associated only with intracranial
atherosclerosis (p < 0.001), whereas ischemic heart disease was
associated with atherosclerosis in both the intracranial (p < 0.001) and
extracranial (p = 0.012) vessels. Smoking was associated with narrowing of
the extracranial vessels only (p = 0.0054). CONCLUSIONS: Compared with
figures from Caucasian and Japanese populations, the extent of intracranial
atherosclerosis is much more severe in Hong Kong Chinese, whereas
atherosclerotic narrowing of the extracranial carotid artery is less severe
in Hong Kong Chinese than in Caucasians.
ARTICLES
Pattern of cerebral atherosclerosis in Hong Kong Chinese. Severity in intracranial and extracranial vessels
Department of Pathology, University of Hong Kong.
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