This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suzuki, Y. Articles by Shibuya, M. Search for Related Content PubMed PubMed Citation Articles by Suzuki, Y. Articles by Shibuya, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB (L)-ARGININE NITRIC OXIDE VASOPRESSIN

Stroke, Vol 24, 1049-1053, Copyright © 1993 by American Heart Association

ARTICLES

Regional differences in the vasodilator response to vasopressin in canine cerebral arteries in vivo

Y Suzuki, S Satoh, H Oyama, M Takayasu and M Shibuya
Department of Neurosurgery, Nagoya University School of Medicine, Japan.

BACKGROUND AND PURPOSE: The aim of this study was to investigate the regional differences in the in vivo vasodilator responses to vasopressin, which is thought to stimulate the release of nitric oxide from the endothelium, in canine cerebral arteries by angiography. METHODS: Angiograms were performed through a catheter inserted directly into the right vertebral artery and were taken periodically after the infusion of vasopressin. The diameters of various segments of the major arteries were measured using a computerized image analysis system. RESULTS: The bolus administration of vasopressin (10 pmol to 1 nmol) into the vertebral artery produced a long-lasting, dose-dependent vasodilation in the major cerebral arteries centering around the circle of Willis. One nanomole of vasopressin appeared to be the optimal dose for producing maximal vasodilation. The internal diameters of the basilar, posterior communicating, and internal carotid arteries experienced the most dilation (approximately 150% that of control) 2 minutes after the infusion of 1 nmol of vasopressin, followed by those of the middle cerebral, the intracranial portion of the vertebral, and the anterior spinal arteries (approximately 130% that of control). The extracranial portion of the vertebral artery (109.8 +/- 4.8% that of control, n = 4) was less sensitive to 1 nmol of vasopressin. Pretreatment with an intracisternal injection of 10 mumol of NG- monomethyl L-arginine suppressed the vasodilator effect of vasopressin and substance P, whereas it did not affect the response to vasoactive intestinal peptide. CONCLUSIONS: These results suggest that the arteries composing the circle of Willis at the base of the brain are more sensitive to nitric oxide release induced by vasopressin compared with other intracranial and extracranial arteries.

This article has been cited by other articles:

				Y. Jeon, J. H. Ryu, Y. J. Lim, C. S. Kim, J.-H. Bahk, S. Z. Yoon, and J. Y. Choi Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients. Eur. J. Cardiothorac. Surg., June 1, 2006; 29(6): 952 - 956. [Abstract] [Full Text] [PDF]

				C.-C. Yeh, C.-T. Wu, C.-H. Lu, C.-P. Yang, and C.-S. Wong Early Use of Small-Dose Vasopressin for Unstable Hemodynamics in an Acute Brain Injury Patient Refractory to Catecholamine Treatment: A Case Report Anesth. Analg., August 1, 2003; 97(2): 577 - 579. [Abstract] [Full Text] [PDF]

				N. Toda and T. Okamura The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels Pharmacol. Rev., June 1, 2003; 55(2): 271 - 324. [Abstract] [Full Text] [PDF]

				C. L. Holmes, B. M. Patel, J. A. Russell, and K. R. Walley Physiology of Vasopressin Relevant to Management of Septic Shock Chest, September 1, 2001; 120(3): 989 - 1002. [Abstract] [Full Text] [PDF]

				L. Balsam and N. Nikbakht L-Arginine inhibits vasopressin-stimulated mesangial cell Ca2+ Am J Physiol Cell Physiol, August 1, 1998; 275(2): C352 - C357. [Abstract] [Full Text] [PDF]

				F. M. FARACI and D. D. HEISTAD Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels Physiol Rev, January 1, 1998; 78(1): 53 - 97. [Abstract] [Full Text] [PDF]

				A. W. Prengel, K. H. Lindner, A. Keller, and R. C. Koehler Cerebral Oxygenation During Cardiopulmonary Resuscitation With Epinephrine and Vasopressin in Pigs Stroke, July 1, 1996; 27(7): 1241 - 1248. [Abstract] [Full Text]

				K. H. Lindner, A. W. Prengel, E. G. Pfenninger, I. M. Lindner, H.-U. Strohmenger, M. Georgieff, and K. G. Lurie Vasopressin Improves Vital Organ Blood Flow During Closed-Chest Cardiopulmonary Resuscitation in Pigs Circulation, January 1, 1995; 91(1): 215 - 221. [Abstract] [Full Text]