This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by LeBlanc, M. H. Articles by Smith, E. E. Search for Related Content PubMed PubMed Citation Articles by LeBlanc, M. H. Articles by Smith, E. E.

Stroke, Vol 24, 1055-1062, Copyright © 1993 by American Heart Association

ARTICLES

Glucose affects the severity of hypoxic-ischemic brain injury in newborn pigs

MH LeBlanc, M Huang, V Vig, D Patel and EE Smith
Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216-4505.

BACKGROUND AND PURPOSE: The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS: In 44 0- to 3-day-old piglets, hypoxic-ischemic central nervous system damage was induced by ligation of both carotid arteries and reduction of their blood pressure to two-thirds normal for one-half hour. In the last 15 minutes of this half hour, oxygen concentration was reduced to 6%. The piglets were randomized to receive either 2 mL/kg 50% dextrose in water followed by 2 mL/kg per hour for 2.5 hours beginning before ischemia or enough insulin to reduce their resting blood sugar to approximately 2 mmol/L. RESULTS: Neurological exam scores in the glucose-treated piglets at 1 day after injury were significantly worse than those in the insulin-treated group. Pathological examination scores were poorer in the glucose-treated group (13.6 +/- 1.9 [mean +/- SEM]) than in the insulin-treated group (24.7 +/- 1.4, P < .01). CONCLUSIONS: Increasing serum glucose during hypoxic-ischemic injury to the newborn piglet's brain worsens brain injury.

This article has been cited by other articles:

				A. Polito, R. R. Thiagarajan, P. C. Laussen, K. Gauvreau, M. S.D. Agus, M. A. Scheurer, F. A. Pigula, and J. M. Costello Association Between Intraoperative and Early Postoperative Glucose Levels and Adverse Outcomes After Complex Congenital Heart Surgery Circulation, November 25, 2008; 118(22): 2235 - 2242. [Abstract] [Full Text] [PDF]

				C. D. Kurth, M. Priestley, J. Golden, J. McCann, and R. Raghupathi REGIONAL PATTERNS OF NEURONAL DEATH AFTER DEEP HYPOTHERMIC CIRCULATORY ARREST IN NEWBORN PIGS J. Thorac. Cardiovasc. Surg., December 1, 1999; 118(6): 1068 - 1077. [Abstract] [Full Text] [PDF]

				R. C. Vannucci and J. M. Perlman Interventions for Perinatal Hypoxic-Ischemic Encephalopathy Pediatrics, December 1, 1997; 100(6): 1004 - 1114. [Full Text] [PDF]

				M. H. LeBlanc, X. Q. Li, M. Huang, D. M. Patel, and E. E. Smith AMPA Antagonist LY293558 Does Not Affect the Severity of Hypoxic-Ischemic Injury in Newborn Pigs Stroke, October 1, 1995; 26(10): 1908 - 1915. [Abstract] [Full Text]

				A. R. Laptook, R. J. T. Corbett, D. Burns, and R. Sterett Neonatal Ischemic Neuroprotection by Modest Hypothermia Is Associated With Attenuated Brain Acidosis Stroke, July 1, 1995; 26(7): 1240 - 1246. [Abstract] [Full Text]