Stroke, Vol 24, 1129-1132, Copyright © 1993 by American Heart Association
F van Kooten, N Hoogerbrugge, P Naarding and PJ Koudstaal
BACKGROUND AND PURPOSE: Hyperglycemia in the acute phase of stroke is
associated with poor outcome. Whether hyperglycemia in nondiabetic stroke
patients is caused by stress is controversial. METHODS: We studied glucose
levels and glycosylated hemoglobin in 91 consecutive patients with acute
stroke admitted within 24 hours after onset of symptoms. In 27 unselected
patients we also measured catecholamines on days 1 and 3 after onset.
RESULTS: Hyperglycemia was found in 39 (43%) of the patients, 55% of whom
either had diabetes mellitus or latent diabetes; the others had idiopathic
hyperglycemia. Norepinephrine levels were associated with the severity of
the stroke (P = .005) and with hypertension (P = .03) but not with glucose
levels, irrespective of whether or not the patients had diabetes.
CONCLUSIONS: We conclude that hyperglycemia in the acute phase of stroke
cannot be explained by increased stress.
ARTICLES
Hyperglycemia in the acute phase of stroke is not caused by stress
Department of Neurology, University Hospital Rotterdam, Dijkzigt, The Netherlands.
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