This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nobili, F. Articles by Rosadini, G. Search for Related Content PubMed PubMed Citation Articles by Nobili, F. Articles by Rosadini, G. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information High Blood Pressure

Stroke, Vol 24, 1148-1153, Copyright © 1993 by American Heart Association

ARTICLES

Regional cerebral blood flow in chronic hypertension. A correlative study

F Nobili, G Rodriguez, S Marenco, F De Carli, M Gambaro, C Castello, R Pontremoli and G Rosadini
Department of Motor Science (Neurophysiopathology), University of Genoa, Italy.

BACKGROUND AND PURPOSE: Cerebral hypoperfusion has occasionally been reported during essential hypertension. We explored regional cerebral blood flow in a large series of neurologically asymptomatic hypertensive patients to determine relations among cerebral blood flow, concomitant main vascular risk factors, and the most common signs of end-organ damage. METHODS: Regional cerebral blood flow was measured by the 133Xe inhalation method in 101 hypertensive patients without clinically apparent central nervous system involvement, including 39 mild to moderate untreated and 62 mild to severe treated patients. RESULTS: Compared with age- and sex-matched normal control subjects, cerebral blood flow was significantly reduced in untreated hypertensive patients (P < .01) and to a lesser extent in treated patients (P = .047). Both regional and global cerebral blood flow reductions were observed in approximately one third of patients in both groups. Analysis of variance failed to show significant correlations between cerebral blood flow and total cholesterol concentration, mean arterial blood pressure, duration of disease, or the presence of retinopathy or left ventricular hypertrophy. In the treated group, the quality of control of hypertension significantly influenced both global cerebral blood flow (P = .007) and cerebrovascular resistance (P < .0001). CONCLUSIONS: Focal or diffuse cerebral hypoperfusion is present even in neurologically asymptomatic hypertensive patients, especially when untreated; good control of blood pressure may preserve cerebral perfusion and reduce cerebrovascular resistance. Regional cerebral blood flow examination represents a relatively simple and low-cost technique to explore the perfusional condition of the brain, one of the main target organs of hypertensive disease.

This article has been cited by other articles:

				S. Ogoh, R. M. Brothers, W. L. Eubank, and P. B. Raven Autonomic Neural Control of the Cerebral Vasculature: Acute Hypotension Stroke, July 1, 2008; 39(7): 1979 - 1987. [Abstract] [Full Text] [PDF]

				D. Hadjiev and P. Mineva Cerebral Blood Flow Changes in Elderly Hypertensive Patients and Cognitive Functions Stroke, November 1, 2007; 38(11): e153 - e153. [Full Text] [PDF]

				A. F. van Raamt, A. P. A. Appelman, W. P. T. M. Mali, Y. van der Graaf, and For the SMART Study Group Arterial Blood Flow to the Brain in Patients with Vascular Disease: The SMART Study. Radiology, August 1, 2006; 240(2): 515 - 521. [Abstract] [Full Text] [PDF]

				V. Novak, A. Chowdhary, B. Farrar, H. Nagaraja, J. Braun, R. Kanard, P. Novak, and A. Slivka Altered cerebral vasoregulation in hypertension and stroke Neurology, May 27, 2003; 60(10): 1657 - 1663. [Abstract] [Full Text] [PDF]

				J. R. Jennings Autoregulation of Blood Pressure and Thought: Preliminary Results of an Application of Brain Imaging to Psychosomatic Medicine Psychosom Med, May 1, 2003; 65(3): 384 - 395. [Abstract] [Full Text] [PDF]

				F. Harrington, B. K. Saxby, I. G. McKeith, K. Wesnes, and G. A. Ford Cognitive Performance in Hypertensive and Normotensive Older Subjects Hypertension, December 1, 2000; 36(6): 1079 - 1082. [Abstract] [Full Text] [PDF]

				K. Y. Lee, Y. H. Sohn, J. S. Baik, G. W. Kim, and J.-S. Kim Arterial Pulsatility as an Index of Cerebral Microangiopathy in Diabetes Stroke, May 1, 2000; 31(5): 1111 - 1115. [Abstract] [Full Text] [PDF]

				T. L. Strassburger, H.-C. Lee, E. M. Daly, J. Szczepanik, J. S. Krasuski, M. J. Mentis, J. A. Salerno, C. DeCarli, M. B. Schapiro, and G. E. Alexander Interactive Effects of Age and Hypertension on Volumes of Brain Structures Stroke, July 1, 1997; 28(7): 1410 - 1417. [Abstract] [Full Text]

				J.T. Moroney, E. Bagiella, D.W. Desmond, M.C. Paik, Y. Stern, and T.K. Tatemichi Risk Factors for Incident Dementia After Stroke: Role of Hypoxic and Ischemic Disorders Stroke, August 1, 1996; 27(8): 1283 - 1289. [Abstract] [Full Text]

				F. Nobili, G. Rodriguez, A. Arrigo, B. Stubinski, E. Rossi, R. Cerri, E. Damasio, G. Rosadini, and A. Marmont Accuracy of 133-xenon regional cerebral blood flow and quantitative electroencephalography in systemic lupus erythematosus Lupus, April 1, 1996; 5(2): 93 - 102. [Abstract] [PDF]

				M.V.L. Bennett, D.E. Pellegrini-Giampietro, J.A. Gorter, E. Aronica, J.A. Connor, and R.S. Zukin The GluR2 Hypothesis: Ca++-permeable AMPA Receptors in Delayed Neurodegeneration Cold Spring Harb Symp Quant Biol, January 1, 1996; 61(0): 373 - 384. [Abstract] [PDF]

				H. Sugimori, S. Ibayashi, K. Fujii, S. Sadoshima, Y. Kuwabara, and M. Fujishima Can Transcranial Doppler Really Detect Reduced Cerebral Perfusion States? Stroke, November 1, 1995; 26(11): 2053 - 2060. [Abstract] [Full Text]