Stroke, Vol 25, 178-182, Copyright © 1994 by American Heart Association
FM Faraci, K Orgren and DD Heistad
BACKGROUND AND PURPOSE--This study examined the hypotheses that (1)
atherosclerosis impairs relaxation of the carotid artery in response to
activation of adenosine triphosphate (ATP)-sensitive potassium channels and
(2) regression of atherosclerosis restores the response toward normal.
METHODS--Isometric tension was measured in rings of carotid artery taken
from normal, atherosclerotic, and regression monkeys and precontracted
submaximally with prostaglandin F2 alpha. RESULTS-- Relaxation in response
to acetylcholine was less in atherosclerotic compared with normal arteries
(5 +/- 6% versus 54 +/- 4% [mean +/- SE] in response to 3 x 10(-8) mol/L
acetylcholine, P < .01). Relaxation in response to aprikalim, a direct
activator of ATP-sensitive potassium channels, was also less in
atherosclerotic than in normal arteries (32 +/- 7% versus 69 +/- 5% during
10(-6) mol/L aprikalim, P < .01). Relaxation in response to aprikalim
but not to acetylcholine or nitroprusside was inhibited almost completely
by glibenclamide (4 mumol/L), a selective inhibitor of ATP-sensitive
potassium channels. Relaxation in response to low but not high (10(-6) to
10(-5) mol/L) concentrations of sodium nitroprusside was less in
atherosclerotic than in normal arteries. Regression of atherosclerosis
tended to restore responses to acetylcholine, but not responses to
nitroprusside or aprikalim, toward normal. CONCLUSIONS--These findings
suggest that atherosclerosis impairs relaxation of the carotid artery in
response to activation of ATP-sensitive channels. Impaired responses may be
due, in part, to nonspecific impairment of relaxation. Regression of
atherosclerosis did not restore responses of the carotid artery toward
normal.
ARTICLES
Impaired relaxation of the carotid artery during activation of ATP- sensitive potassium channels in atherosclerotic monkeys
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
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