Stroke, Vol 25, 74-78, Copyright © 1994 by American Heart Association
M Nagayama, Y Shinohara and T Nagayama
BACKGROUND AND PURPOSE--Serum lipoprotein(a) level is genetically
determined and remains almost constant throughout life. Based on this
property, we investigated the serum lipoprotein(a) levels of ischemic
stroke patients in the chronic stage (mean period after stroke, 27 months)
and its relation to the types of ischemic stroke. METHODS--We measured
serum lipoprotein(a) levels in 101 patients with chronic ischemic stroke
and 37 normal control subjects, taking the clinical profiles into
consideration. RESULTS--Lipoprotein(a) levels in patients with
atherothrombotic stroke were 28.0 +/- 19.6 mg/dL (mean +/- SD), which were
significantly (P < .01) higher than those in patients with lacunar
stroke and in normal control subjects (16.4 +/- 13.5 and 11.7 +/- 10.5
mg/dL, respectively). The lipoprotein(a) levels in patients with
atherothrombotic stroke were significantly higher in the subgroup who were
a younger age at onset: onset before age 50 years, 35.3 +/- 20.5; onset at
age 50 to 59, 35.4 +/- 21.7; onset at age 60 to 69, 17.0 +/- 12.8; and
onset at age 70 or older, 16.3 +/- 6.8 mg/dL (P < .01 for onset before
age 50 versus 60 to 69 years or 70 years or older; P < .01 for onset at
50 to 59 years versus 60 to 69 years or 70 years or older). Serum
lipoprotein(a) was significantly increased (40.2 +/- 20.1 mg/dL) in young
adults with atherothrombotic stroke (onset at younger than age 45 years)
compared with that in patients older than 45 years (P < .01).
CONCLUSIONS--We conclude that lipoprotein(a) is a genetic, independent, and
critical risk factor for ischemic stroke, especially in young adults.
ARTICLES
Lipoprotein(a) and ischemic cerebrovascular disease in young adults
Department of Neurology, Tokai University School of Medicine, Isehara, Japan.
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