Stroke, Vol 25, 318-327, Copyright © 1994 by American Heart Association
TA Manolio, RA Kronmal, GL Burke, V Poirier, DH O'Leary, JM Gardin, LP Fried, EP Steinberg and RN Bryan
BACKGROUND AND PURPOSE: Cerebral magnetic resonance imaging often detects
abnormalities whose significance is unknown. The prevalence and correlates
of findings such as ventricular enlargement, sulcal widening, and increased
white matter signal intensity were examined in 303 men and women aged 65 to
95 years participating in a multicenter study of cardiovascular disease.
METHODS: Cerebral magnetic resonance imaging was performed and interpreted
according to a standard protocol, and findings were correlated with
measures of cardiovascular disease and its risk factors. RESULTS: Measures
of cerebral atrophy increased with age and were greater in men than in
women (each P < .01). Ventricular enlargement and sulcal widening were
associated with prior stroke, hypertension, diabetes, and white race (each
P < .03). Extent of white matter hyperintensity was associated with age,
prior stroke, hypertension, and use of diuretics (each P < .004). On
multivariate analysis, age, male gender, white race, and prior stroke
retained strong associations with increased ventricular and sulcal scores.
After adjustment for age, prior stroke, and other risk factors, white
matter hyperintensity was associated with atherosclerosis as measured by
increased internal carotid artery thickness on ultrasound. CONCLUSIONS:
Cerebral atrophy and white matter hyperintensity are common in the elderly
and are associated with age, prior stroke, and known cardiovascular risk
factors. Though these findings have been suggested to represent normal
aging, their wide variability and associations with cardiovascular disease
argue against their inevitability with advancing age and support the need
to identify modifiable risk factors for these abnormalities.
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Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study
Division of Epidemiology and Clinical Applications, National Heart, Lung and Blood Institute, Bethesda, MD 20892.
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R. Schmidt, H. Schmidt, F. Fazekas, M. Schumacher, K. Niederkorn, P. Kapeller, V. Weinrauch, and G. M. Kostner Apolipoprotein E Polymorphism and Silent Microangiopathy-Related Cerebral Damage : Results of the Austrian Stroke Prevention Study Stroke, May 1, 1997; 28(5): 951 - 956. [Abstract] [Full Text]
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D. Liao, L. Cooper, J. Cai, J. F. Toole, N. R. Bryan, R. G. Hutchinson, and H. A. Tyroler Presence and Severity of Cerebral White Matter Lesions and Hypertension, Its Treatment, and Its Control: The ARIC Study Stroke, December 1, 1996; 27(12): 2262 - 2270. [Abstract] [Full Text]
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R. Schmidt, M. Hayn, F. Fazekas, P. Kapeller, and H. Esterbauer Magnetic Resonance Imaging White Matter Hyperintensities in Clinically Normal Elderly Individuals: Correlations With Plasma Concentrations of Naturally Occurring Antioxidants Stroke, November 1, 1996; 27(11): 2043 - 2047. [Abstract] [Full Text]
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T. A. Manolio, R. A. Kronmal, G. L. Burke, D. H. O'Leary, and T. R. Price Short-term Predictors of Incident Stroke in Older Adults: The Cardiovascular Health Study Stroke, September 1, 1996; 27(9): 1479 - 1486. [Abstract] [Full Text]
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W.T. Longstreth, T. A. Manolio, A. Arnold, G. L. Burke, N. Bryan, C. A. Jungreis, P. L. Enright, D. O'Leary, and L. Fried Clinical Correlates of White Matter Findings on Cranial Magnetic Resonance Imaging of 3301 Elderly People: The Cardiovascular Health Study Stroke, August 1, 1996; 27(8): 1274 - 1282. [Abstract] [Full Text]
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A. Auperin, C. Berr, C. Bonithon-Kopp, P.-J. Touboul, I. Ruelland, P. Ducimetiere, and A. Alperovitch Ultrasonographic Assessment of Carotid Wall Characteristics and Cognitive Functions in a Community Sample of 59- to 71-Year-Olds Stroke, August 1, 1996; 27(8): 1290 - 1295. [Abstract] [Full Text]
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H. Fukuda and M. Kitani Cigarette Smoking Is Correlated With the Periventricular Hyperintensity Grade on Brain Magnetic Resonance Imaging Stroke, April 1, 1996; 27(4): 645 - 649. [Abstract] [Full Text]
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H. Fukuda and M. Kitani Differences Between Treated and Untreated Hypertensive Subjects in the Extent of Periventricular Hyperintensities Observed on Brain MRI Stroke, September 1, 1995; 26(9): 1593 - 1597. [Abstract] [Full Text]
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R. G. Hart, B. S. Boop, and D. C. Anderson Oral Anticoagulants and Intracranial Hemorrhage : Facts and Hypotheses Stroke, August 1, 1995; 26(8): 1471 - 1477. [Abstract] [Full Text]
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A. Ylikoski, T. Erkinjuntti, R. Raininko, S. Sarna, R. Sulkava, and R. Tilvis White Matter Hyperintensities on MRI in the Neurologically Nondiseased Elderly : Analysis of Cohorts of Consecutive Subjects Aged 55 to 85 Years Living at Home Stroke, July 1, 1995; 26(7): 1171 - 1177. [Abstract] [Full Text]
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