This Article Order Full text via Infotrieve Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sabatini, U. Articles by Lenzi, G. L. Search for Related Content PubMed PubMed Citation Articles by Sabatini, U. Articles by Lenzi, G. L.

Stroke, Vol 25, 514-517, Copyright © 1994 by American Heart Association

ARTICLES

Motor recovery after early brain damage. A case of brain plasticity

U Sabatini, D Toni, P Pantano, G Brughitta, A Padovani, L Bozzao and GL Lenzi
Neuroradiology Unit, University La Sapienza, Rome, Italy.

BACKGROUND: Motor recovery is remarkable when the brain is damaged early in life. We describe a case of early damage to the right hemisphere with remarkable reorganization and plastic functional changes, studied by computed neuroimaging. CASE DESCRIPTION: A 31-year- old man had a left-sided hemiplegia at the age of 12, followed by good motor recovery despite a large right cortical-subcortical lesion. Single-photon emission computed tomography with motor activation study showed cerebral blood flow increase in the left premotor and sensorimotor cortices irrespective of the hand he was moving, without flow changes in the right hemisphere. CONCLUSIONS: A remarkable reorganization and plastic brain functional changes occurred in a patient after early diffuse damage of the right hemisphere. The study points to a potential role of ipsilateral cortical efferent pathways in subserving hand movements after early cerebral damage.

This article has been cited by other articles:

				P. Pantano, G. D. Iannetti, F. Caramia, C. Mainero, S. Di Legge, L. Bozzao, C. Pozzilli, and G. L. Lenzi Cortical motor reorganization after a single clinical attack of multiple sclerosis Brain, July 1, 2002; 125(7): 1607 - 1615. [Abstract] [Full Text] [PDF]

				G.-J. M. Rutten, N. F. Ramsey, P. C. Van Rijen, H. Franssen, and C. W. M. Van Veelen Interhemispheric Reorganization of Motor Hand Function to the Primary Motor Cortex Predicted With Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation J Child Neurol, April 1, 2002; 17(4): 292 - 297. [Abstract] [PDF]

				A. W. Dromerick, D. F. Edwards, and M. Hahn Does the Application of Constraint-Induced Movement Therapy During Acute Rehabilitation Reduce Arm Impairment After Ischemic Stroke? Stroke, December 1, 2000; 31(12): 2984 - 2988. [Abstract] [Full Text] [PDF]

				U. Sabatini, K. Boulanouar, N. Fabre, F. Martin, C. Carel, C. Colonnese, L. Bozzao, I. Berry, J. L. Montastruc, F. Chollet, et al. Cortical motor reorganization in akinetic patients with Parkinson's disease: A functional MRI study Brain, February 1, 2000; 123(2): 394 - 403. [Abstract] [Full Text] [PDF]

				H G. Wieser, K. Henke, D. Zumsteg, E. Taub, Y. Yonekawa, and A. Buck Activation of the left motor cortex during left leg movements after right central resection J. Neurol. Neurosurg. Psychiatry, October 1, 1999; 67(4): 487 - 491. [Abstract] [Full Text] [PDF]

				G. Nelles, G. Spiekermann, M. Jueptner, G. Leonhardt, S. Muller, H. Gerhard, and H. C. Diener Reorganization of Sensory and Motor Systems in Hemiplegic Stroke Patients : A Positron Emission Tomography Study Stroke, August 1, 1999; 30(8): 1510 - 1516. [Abstract] [Full Text] [PDF]

				E. Achten, G. D. Jackson, J. A. Cameron, D. F. Abbott, D. L. Stella, and G. C. A. Fabinyi Presurgical Evaluation of the Motor Hand Area with Functional MR Imaging in Patients with Tumors and Dysplastic Lesions Radiology, February 1, 1999; 210(2): 529 - 538. [Abstract] [Full Text]

				R.-A. Muller, R. D. Rothermel, M. E. Behen, O. Muzik, T. J. Mangner, and H. T. Chugani Differential Patterns of Language and Motor Reorganization Following Early Left Hemisphere Lesion: A PET Study Arch Neurol, August 1, 1998; 55(8): 1113 - 1119. [Abstract] [Full Text] [PDF]

				M. Silvestrini, L. M. Cupini, F. Placidi, M. Diomedi, and G. Bernardi Bilateral Hemispheric Activation in the Early Recovery of Motor Function After Stroke Stroke, July 1, 1998; 29(7): 1305 - 1310. [Abstract] [Full Text] [PDF]

				S. C. Cramer, G. Nelles, R. R. Benson, J. D. Kaplan, R. A. Parker, K. K. Kwong, D. N. Kennedy, S. P. Finklestein, and B. R. Rosen A Functional MRI Study of Subjects Recovered From Hemiparetic Stroke Stroke, December 1, 1997; 28(12): 2518 - 2527. [Abstract] [Full Text]