Stroke, Vol 25, 864-868, Copyright © 1994 by American Heart Association
T Shishido, R Suzuki, L Qian and K Hirakawa
BACKGROUND AND PURPOSE: To determine the role of superoxide anions in the
pathogenesis of cerebral vasospasm after aneurysmal subarachnoid
hemorrhage, we studied the preventive effect of human recombinant
copper-zinc superoxide dismutase (h-r SOD) in a rabbit subarachnoid
hemorrhage (SAH) model. METHODS: Forty-five rabbits receiving
intracisternal injection of 3 mL autologous nonheparinized blood or 3 mL
saline were divided into four groups as follows: (1) saline injected and no
treatment (control group, n = 6); (2) blood injected and no treatment (SAH
group, n = 20); (3) blood injected and treated by multiple intracisternal
injections of 30,000 U of h-r SOD in 0.5 mL saline (SOD group, n = 9); and
(4) blood injected and treated by multiple intracisternal injections of 0.5
mL saline (saline group, n = 10). Serial angiograms were performed after
the blood injection, and the diameter of the basilar artery was measured.
Three animals from the control group and five animals from the SAH and SOD
groups each were killed 2 days after SAH, and their basilar arteries were
processed for transmission electron microscopic observations. RESULTS: In
the SAH and saline groups, the diameter of the basilar arteries was
significantly reduced (28 +/- 14% and 27 +/- 9%, respectively) at 2 days
after the blood injection, then recovered to pre-SAH levels until 11 days.
In the SOD group, the diameter of the basilar artery was only minimally
changed during the follow-up period. Transmission electron microscopy
revealed endothelial injury in all basilar arteries in the SAH group,
whereas endothelial injury was minimal in the SOD group. CONCLUSIONS: We
determined that h-r SOD prevents the occurrence of vasospasm, possibly as a
result of preventing endothelial injury initiated by superoxide anions.
ARTICLES
The role of superoxide anions in the pathogenesis of cerebral vasospasm
Department of Neurosurgery, Tokyo Medical and Dental University, Japan.
This article has been cited by other articles:
 |
|
 |
|
  G. S. Kim, J. E. Jung, K. Niizuma, and P. H. Chan CK2 Is a Novel Negative Regulator of NADPH Oxidase and a Neuroprotectant in Mice after Cerebral Ischemia J. Neurosci., November 25, 2009; 29(47): 14779 - 14789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Watanabe, F. M. Faraci, and D. D. Heistad Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2653 - H2658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Watanabe, Y. Chu, J. J. Andresen, H. Nakane, F. M. Faraci, and D. D. Heistad Gene Transfer of Extracellular Superoxide Dismutase Reduces Cerebral Vasospasm After Subarachnoid Hemorrhage Stroke, February 1, 2003; 34(2): 434 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Kim, Y. S. Suh, M.-S. Lee, K. Y. Kim, J. H. Lee, H. S. Lee, K. W. Hong, and C. D. Kim Vascular NAD(P)H Oxidase Triggers Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage in Rats Stroke, November 1, 2002; 33(11): 2687 - 2691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. McGirt, A. Parra, H. Sheng, Y. Higuchi, T. D. Oury, D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner Attenuation of Cerebral Vasospasm After Subarachnoid Hemorrhage in Mice Overexpressing Extracellular Superoxide Dismutase Stroke, September 1, 2002; 33(9): 2317 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Lee, D. G. Na, K. H. Choi, K. J. Kim, J. W. Ryoo, S. Y. Lee, and Y.-L. Suh Subcortical Low Intensity on MR Images of Meningitis, Viral Encephalitis, and Leptomeningeal Metastasis AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 535 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Satoh, A. D. Parent, and J. H. Zhang Inhibitory Effect With Antisense Mitogen-Activated Protein Kinase Oligodeoxynucleotide Against Cerebral Vasospasm in Rats Stroke, March 1, 2002; 33(3): 775 - 781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saito, H. Kamii, I. Kato, S. Takasawa, T. Kondo, P. H. Chan, H. Okamoto, T. Yoshimoto, and R. L. Macdonald Transgenic CuZn-Superoxide Dismutase Inhibits NO Synthase Induction in Experimental Subarachnoid Hemorrhage Editorial Comment Stroke, July 1, 2001; 32(7): 1652 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Park, C. Metais, H. B. Dai, M. E. Comunale, and F. W. Sellke Microvascular Endothelial Dysfunction and its Mechanism in a Rat Model of Subarachnoid Hemorrhage Anesth. Analg., April 1, 2001; 92(4): 990 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mori, K. Nagata, T. Town, J. Tan, T. Matsui, and T. Asano Intracisternal Increase of Superoxide Anion Production in a Canine Subarachnoid Hemorrhage Model Stroke, March 1, 2001; 32(3): 636 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Satoh, I. Date, M. Nakajima, K. Takahashi, K. Iseda, T. Tamiya, T. Ohmoto, Y. Ninomiya, S. Asari, and R. L. Macdonald Inhibition of Poly(ADP-Ribose) Polymerase Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbits Editorial Comment Stroke, January 1, 2001; 32(1): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Toyoda, F. M. Faraci, Y. Watanabe, T. Ueda, J. J. Andresen, Y. Chu, S. Otake, and D. D. Heistad Gene Transfer of Calcitonin Gene-Related Peptide Prevents Vasoconstriction After Subarachnoid Hemorrhage Circ. Res., October 27, 2000; 87(9): 818 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Charpentier, G. Audibert, F. Guillemin, T. Civit, X. Ducrocq, S. Bracard, H. Hepner, L. Picard, and M. C. Laxenaire Multivariate Analysis of Predictors of Cerebral Vasospasm Occurrence After Aneurysmal Subarachnoid Hemorrhage Stroke, July 1, 1999; 30(7): 1402 - 1408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kamii, I. Kato, H. Kinouchi, P. H. Chan, C. J. Epstein, A. Akabane, H. Okamoto, T. Yoshimoto, and C. Y. Hsu Amelioration of Vasospasm After Subarachnoid Hemorrhage in Transgenic Mice Overexpressing CuZn–Superoxide Dismutase • Editorial Comment Stroke, April 1, 1999; 30(4): 867 - 872. [Abstract] [Full Text] [PDF]
|
|