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(Stroke. 1995;26:2358-2360.)
© 1995 American Heart Association, Inc.

Articles

Effect of Acetazolamide on Regional Cerebral Oxygen Saturation and Regional Cerebral Blood Flow

Makio Kaminogo, MD; Akio Ichikura, MD; Shobu Shibata, MD; Tamotsu Toba, MD Masahiro Yonekura, MD

From the Department of Neurosurgery, Nagasaki University School of Medicine (M.K., A.I., S.S.), and the Department of Neurosurgery, Nagasaki Central Hospital (T.T., M.Y.), Nagasaki, Japan.

Correspondence to Makio Kaminogo, Department of Neurosurgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto-machi, Nagasaki 852, Japan.

Background and Purpose To verify whether the monitoring of regional cerebral oxygen saturation (rSO₂) with transcranial near-infrared spectroscopy would successfully reflect changes in intracranial hemodynamics but not changes in extracranial compartment, we measured rSO₂ and regional cerebral blood flow (rCBF) simultaneously in seven patients with cerebral ischemia and five normal volunteers before and after acetazolamide administration.

Summary of Report The baseline values of rSO₂ and rCBF were 64.2±5.6% and 53.9±11.1 mL/100 g per minute, respectively. rCBF increased by 44.4±23.3% and rSO₂ significantly increased to 69.6±5.6% after acetazolamide administration. Bilateral simultaneous measurement of rSO₂ indicated a tendency that the larger the rSO₂, the greater the %rCBF. The relationship between rSO₂ level and rCBF value fit significantly on the theoretical curve calculated from Fick's equation.

Conclusions It is suggested that monitoring of rSO₂ with INVOS-3100 could be a useful indicator in the evaluation of intracranial hemodynamic changes.

Key Words: acetazolamide • cerebral blood flow • oxyhemoglobins

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