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(Stroke. 1995;26:271-276.)
© 1995 American Heart Association, Inc.

Articles

Cat Cerebral Arteries Are Functionally Innervated by Serotoninergic Fibers From Central and Peripheral Origins

María Jesús Moreno, PhD; Angel L. López de Pablo, PhD; María Victoria Conde, PhD Emilio J. Marco, PhD

From the Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid (Spain).

Correspondence to Dr Emilio J. Marco, Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain.

Background and Purpose Tryptophan hydroxylase activity and responses to tyramine were analyzed in cat cerebral arteries to investigate serotoninergic innervation.

Methods Enzymatic activity and responses to tyramine were measured in vessels from animals subjected to cervical gangliectomy and dorsal and median raphe nuclei lesions.

Results Tryptophan hydroxylase activity in cat cerebral arteries was reduced after ganglia removal and raphe nuclei destruction. Contractile responses of the middle cerebral artery after gangliectomy were decreased by ketanserine. Dorsal raphe nucleus destruction had a significant effect on the contractile response, whereas median raphe nucleus destruction had only a slight effect.

Conclusions Cat cerebral arteries receive serotoninergic innervation from central and peripheral origins. (Stroke. 1995;26:271-276.)

Key Words: cerebral arteries • cerebral blood flow • serotonin • cats

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				E. J. Marco, M. J. Moreno, A. L. L. de Pablo, and H. A. Kontos Local Treatments of Dorsal Raphe Nucleus Induce Changes in Serotonergic Activity in Rat Major Cerebral Arteries • Editorial Comment Stroke, August 1, 1999; 30(8): 1695 - 1701. [Abstract] [Full Text] [PDF]