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(Stroke. 1995;26:415-417.)
© 1995 American Heart Association, Inc.

Articles

Human Leukocyte Antigen in Patients With Moyamoya Disease

Masaru Aoyagi, MD; Kazuo Ogami, BS; Yoshiharu Matsushima, MD; Manabu Shikata, BS; Mari Yamamoto, PhD Kiyotaka Yamamoto, PhD

From the Department of Neurosurgery, Tokyo Medical and Dental University, Bunkyo-ku (M.A., Y.M.), and the Department of Cell Biology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku (M.A., K.O., M.S., M.Y., K.Y.), Tokyo, Japan.

Correspondence to Masaru Aoyagi, MD, Department of Neurosurgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113, Japan.

Background and Purpose Progressive stenosis or occlusion of bilateral internal carotid arteries by fibrocellular intimal thickening results in cerebral ischemia in moyamoya disease. In an attempt to elucidate the still-unknown etiologic factors in moyamoya disease, we assessed human leukocyte antigens in patients with this disease.

Methods We investigated 32 unrelated Japanese patients with moyamoya disease for typing of human leukocyte antigen A, B, C, and DR/DQ and compared the results with those from 178 unrelated control subjects.

Results We found a significant association of human leukocyte antigen B51 with moyamoya disease (corrected P<.05, ² test). Although no significant associations were observed in DR/DQ typing, the frequency of the B51-DR4 combination was significantly higher in moyamoya patients than in control subjects (P<.002, Fisher's exact test).

Conclusions These findings suggest that there may be a genetic predisposition for moyamoya disease and that host factors may play a role in the development of intimal thickening in early childhood.

Key Words: cerebrovascular disease • leukocytes • moyamoya disease

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