(Stroke. 1995;26:956-960.)
© 1995 American Heart Association, Inc.
Articles |
Carotid Artery Wall Intima-Media Thickness Is Associated With Insulin-Mediated Glucose Disposal in Men at High and Low Coronary Risk
From the Department of Medicine (S. Agewall, B.F., S. Attvall, V.U.) and Wallenberg Laboratory for Cardiovascular Research (I.W., J.W.), Sahlgrenska University Hospital, Göteborg University (Sweden).
Correspondence to Stefan Agewall, MD, PhD, Department of Medicine, Sahlgrenska University Hospital, Göteborg University, S-413 45 Göteborg, Sweden.
Background and Purpose The aim of this investigation was to examine the relationship between insulin sensitivity and intima-media thickness in the common carotid artery.
Methods Ultrasound examinations of the common carotid artery and hyperinsulinemic euglycemic clamp examinations were performed in a group (n=25) of men aged 57 to 77 years at high risk for atherosclerotic disease (hypertension and at least one of the following factors: hypercholesterolemia and/or smoking) and in an age-matched low-risk group (n=23) with no cardiovascular risk factors. Subjects with cardiovascular disease or diabetes mellitus were excluded.
Results A significant negative relationship between insulin sensitivity index and common carotid maximum intima-media thickness was observed in both the high-risk group (r=-.45, P<.05) and in the low-risk group (r=-.59, P<.01).
Conclusions Our results suggest that an increase in intima-media thickness, as a possible expression of early atherosclerosis, is negatively related to insulin sensitivity.
Key Words: atherosclerosis • carotid arteries • insulin • ultrasonics
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