This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Okudaira, Y. Articles by Sato, K. Search for Related Content PubMed PubMed Citation Articles by Okudaira, Y. Articles by Sato, K.

(Stroke. 1995;26:1234-1239.)
© 1995 American Heart Association, Inc.

Articles

Evaluation of the Acetazolamide Test

Vasoreactivity and Cerebral Blood Volume

Yojiro Okudaira, MD; Kuniaki Bandoh, MD; Hajime Arai, MD Kiyoshi Sato, MD

From the Department of Neurosurgery, Juntendo University, Tokyo, Japan.

Background and Purpose We evaluated the potential usefulness of the acetazolamide test by investigating whether acetazolamide vasoreactivity reflected the change in resting cerebral blood volume caused by compensatory vasodilation due to a decline in cerebral perfusion pressure.

Methods We measured resting and acetazolamide-activated cerebral blood flow with a stable xenon-enhanced CT system and resting cerebral blood volume with the subtraction technique using contrast-enhanced CT in 30 patients with various diseases. These parameters were measured in the anterior, middle, and posterior cerebral arterial territories of both hemispheres separately. We evaluated the statistical relationships between resting cerebral blood volume and vasoreactivity in these three territories, and the significance of the correlations was tested by ANOVA/ANCOVA to adjust for the double entries.

Results Significant negative linear relationships were demonstrated between the resting cerebral blood volume and the change in cerebral blood flow, expressed as a percentage induced by acetazolamide activation, for the anterior (r=-.607, P=.0004), middle (r=-.551, P=.0015), and posterior (r=-.523, P=.0078) cerebral arterial territories and between the resting cerebral blood volume and the increase in cerebral blood flow (absolute values) for the anterior (r=-.512, P=.0164) and middle (r=-.523, P=.0001) but not the posterior (r=-.571, P=.0563) cerebral arterial territories.

Conclusions The acetazolamide test appears to be useful for the investigation of compensatory vasodilation: the vasoreactivity can be calculated as the increased cerebral blood flow expressed as a percentage or an absolute value, which both reflect cerebral blood volume directly.

Key Words: acetazolamide • cerebral blood flow • cerebral blood volume • tomography

This article has been cited by other articles:

				G TAN and T GODDARD Neuroimaging applications of multislice CT perfusion Imaging, June 1, 2007; 19(2): 142 - 152. [Abstract] [Full Text] [PDF]

				M l. Cour, J F Kiilgaard, T Eysteinsson, A K Wiencke, K Bang, J Dollerup, P K Jensen, and E Stefánsson Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide Br. J. Ophthalmol., September 1, 2000; 84(9): 1045 - 1049. [Abstract] [Full Text]

				S. J. Schreiber, S. Gottschalk, M. Weih, A. Villringer, and J. M. Valdueza Assessment of Blood Flow Velocity and Diameter of the Middle Cerebral Artery during the Acetazolamide Provocation Test by Use of Transcranial Doppler Sonography and MR Imaging AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1207 - 1211. [Abstract] [Full Text] [PDF]

				M. Wiart, Y. Berthezene, P. Adeleine, P. Feugier, P. Trouillas, J.-C. Froment, and N. Nighoghossian Vasodilatory Response of Border Zones to Acetazolamide Before and After Endarterectomy : An Echo Planar Imaging-Dynamic Susceptibility Contrast-Enhanced MRI Study in Patients With High-Grade Unilateral Internal Carotid Artery Stenosis Stroke, July 1, 2000; 31(7): 1561 - 1565. [Abstract] [Full Text] [PDF]

				D. G. Nabavi, A. Cenic, R. A. Craen, A. W. Gelb, J. D. Bennett, R. Kozak, and T.-Y. Lee CT Assessment of Cerebral Perfusion: Experimental Validation and Initial Clinical Experience Radiology, October 1, 1999; 213(1): 141 - 149. [Abstract] [Full Text]

				R. Brilla, D. G. Nabavi, G. Schulte-Altedorneburg, V. Kemeny, D. Reichelt, S. Evers, U. Schiemann, and I.-W. Husstedt Cerebral Vasculopathy in HIV Infection Revealed by Transcranial Doppler : A Pilot Study Stroke, April 1, 1999; 30(4): 811 - 813. [Abstract] [Full Text] [PDF]

				P. T. Ulrich, S. Kroppenstedt, A. Heimann, O. Kempski, and B. G. Lyeth Laser-Doppler Scanning of Local Cerebral Blood Flow and Reserve Capacity and Testing of Motor and Memory Functions in a Chronic 2-Vessel Occlusion Model in Rats • Editorial Comment Stroke, November 1, 1998; 29(11): 2412 - 2420. [Abstract] [Full Text] [PDF]

				Y. Okudaira, H. Arai, and K. Sato Cerebral Blood Flow Alteration by Acetazolamide During Carotid Balloon Occlusion : Parameters Reflecting Cerebral Perfusion Pressure in the Acetazolamide Test Stroke, April 1, 1996; 27(4): 617 - 621. [Abstract] [Full Text]