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(Stroke. 1996;27:7-9.)
© 1996 American Heart Association, Inc.

Articles

Hypertension, Stroke, and Coronary Heart Disease in Relatives of Patients With Subarachnoid Hemorrhage

J.E.C. Bromberg, MD; G.J.E. Rinkel, MD; A. Algra, MD; U.A.C. van den Berg, MD; M.L.R. Tjin-A-Ton, MD J. van Gijn, MD, FRCPE

From the University Department of Neurology, Utrecht, Netherlands.

Correspondence to Jacoline E.C. Bromberg, MD, University Department of Neurology, PO Box 85500, 3508 GA Utrecht, Netherlands.

Background and Purpose First-degree relatives of patients with subarachnoid hemorrhage (SAH) have a three to seven times greater risk of SAH than second-degree relatives and than the general population. If hypertension, which is in part genetically determined, contributes to this increased risk, the frequency of hypertension and its sequelae would be expected to be higher in first- than in second-degree relatives of patients with SAH.

Methods We compared the reported frequency of hypertension, stroke, and coronary heart disease between 1290 first- and 3588 second-degree relatives of a prospective series of patients with SAH.

Results The relative risk adjusted for age and survival status in first-degree relatives was 2.3 (95% confidence interval [CI], 1.9 to 2.9) for hypertension, 1.8 (95% CI, 1.3 to 2.4) for stroke, and 1.9 (95% CI, 1.5 to 2.3) for coronary heart disease.

Conclusions Hypertension is a familial factor contributing to the risk of SAH. Hypertension should be sought and treated in first-degree relatives of patients with SAH to reduce the increased risk of cerebrovascular and cardiovascular diseases.

Key Words: subarachnoid hemorrhage • hereditary disease • hypertension

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