(Stroke. 1996;27:2204-2206.)
© 1996 American Heart Association, Inc.
Articles |
Acute Infection as a Risk Factor for Ischemic Stroke
the Department of Neurology, Tel Aviv Medical Center, and the Faculty of Sackler Medicine, Tel Aviv University, Israel.
Correspondence to N.M. Bornstein, MD, Stroke Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel.
Background and Purpose Prior studies have demonstrated that infections might precipitate ischemic strokes (IS), but the role of infection as a risk factor remains unclear. We conducted a case-control study to investigate this issue.
Methods Consecutive patients (n=182) with acute IS were examined within 48 hours after admission to our center. A history of acute infections within 2 months before the IS was assessed by means of a specially designed questionnaire that was also given to a control group consisting of 194 consecutive patients who were seen in our outpatient clinic and had suffered IS at least 6 months previously.
Results The prevalence of acute infection in the study group was significantly higher (44193/=24.2%) than in the control group (19193/=9.7%; odds ratio, 2.93; 95% confidence interval, 1.64 to 5.26; P=.0002) and infection occurred mostly within 1 week before the IS (41/44). Neither the severity of the IS nor the type of the infection was significantly different in patients and control subjects.
Conclusions Acute infections of different types constitute a risk factor for IS, particularly within 1 week of the event. However, the severity of the stroke is not related to this factor.
Key Words: cerebral ischemia • epidemiology • infection • risk factors
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