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(Stroke. 1996;27:324-326.)
© 1996 American Heart Association, Inc.

Articles

Functional Outcome in Rats Transferred to an Enriched Environment 15 Days After Focal Brain Ischemia

Barbro B. Johansson, MD, PhD

From the Department of Neurology, Lund University Hospital (Sweden).

Correspondence to Barbro B. Johansson, MD, PhD, Department of Neurology, Lund University Hospital, S-221 85 Lund, Sweden. E-mail barbro.johansson@neurol.lu.se.

Background and Purpose The aim was to determine whether a delayed transfer to an enriched environment improves outcome after focal brain ischemia.

Methods Performance on a rotating pole, prehensile traction, limb placement, and postural reflexes were tested in 15 spontaneously hypertensive rats housed in standard laboratory cages for 2 weeks after middle cerebral artery ligation. Seven of the 15 rats were then transferred to an enriched environment, and the two groups were tested 1, 3, and 5 weeks later.

Results The enriched environment significantly improved pole performance, prehensile traction, and limb placement.

Conclusions Delayed postoperative environmental enrichment improves outcome in experimental stroke.

Key Words: behavior, animal • stroke, experimental • stroke outcome • rats

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