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(Stroke. 1996;27:363-369.)
© 1996 American Heart Association, Inc.

Articles

DNA Damage and Repair in Central Nervous System Injury

National Institute of Neurological Disorders and Stroke Workshop Summary

Michael Chopp, PhD; Pak H. Chan, PhD; Chung Y. Hsu, MD, PhD; Mary Ellen Cheung, PhD Thomas P. Jacobs, PhD

From the Neurology Department, Henry Ford Health Sciences Center, Detroit, and the Physics Department, Oakland University, Rochester, Mich (M.C.); the Departments of Neurosurgery and Neurology, University of California at San Francisco (P.H.C.); the Neurology Department, Washington University School of Medicine, St Louis, Mo (C.Y.H.); and the Division of Stroke and Trauma, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md (M.E.C., T.P.J.).

Correspondence to Thomas P. Jacobs, PhD, Division of Stroke and Trauma, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 7550 Wisconsin Ave, Bethesda, MD 20892.

Background and Purpose DNA damage and repair are areas of research with important implications for stroke and cerebral trauma. DNA damage is present in central nervous system (CNS) injury, and defects in repair mechanisms are associated with neurodegenerative disease.

Methods A workshop, DNA Damage and Repair in CNS Injury, was organized by the National Institute of Neurological Disorders and Stroke in Bethesda, Md, on September 11, 1995. The objective of this workshop was to promote inquiry and to foster application of research in DNA damage and repair after stroke and trauma.

Results The participants discussed the connection between the fields of DNA damage and repair and stroke and trauma and identified gaps in knowledge to be filled to expand research of DNA damage and repair in CNS injury. Specific recommendations were made targeting research opportunities in the areas of DNA repair and damage in stroke and trauma.

Conclusions Research in the science of DNA injury and repair will likely provide new and important information on mechanisms of cell damage and provide opportunities for the development of novel and effective therapies to reduce CNS injury in stroke and trauma.

Key Words: cerebral ischemia • DNA damage • DNA repair • central nervous system • genetics • apoptosis

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