(Stroke. 1996;27:654-660.)
© 1996 American Heart Association, Inc.
Articles |
Factors of Carotid Arterial Enlargement in a Population Aged 59 to 71 Years
The EVA Study
From INSERM U 258 (C.B.-K., P.D.), Centre de Diagnostic et de Prévention Neurovasculaire (P.J.T.), and INSERM U 360 (C.B.), Paris; and Centre d'examen EVA (C.M.), Nantes, France.
Correspondence to Claire Bonithon-Kopp, MD, PhD, INSERM U 258, Hôpital Broussais, 96 rue Didot, 75674 Paris Cedex 14, France.
Background and Purpose Factors of carotid arterial enlargement are not well known in general populations. The purpose of this study was to assess the cross-sectional associations of arterial wall lesions and cardiovascular risk factors with carotid lumen diameter in elderly subjects.
Methods B-mode ultrasound examinations of the carotid arteries and risk factor assessment were made in 1272 participants in the EVA (Etude sur le vieillissement artériel) Study, a longitudinal study designed to evaluate vascular and cognitive aging in men and women aged 59 to 71 years. Ultrasound examinations included measurements of intima-media thickness (IMT) and interadventitial and lumen diameters of the common carotid arteries and quantification of atherosclerotic plaques in extracranial carotid arteries.
Results Men showed greater IMT and interadventitial and lumen diameters of the common carotid arteries than did women. In both sexes, common IMT and plaque score were positively associated with common interadventitial and lumen diameters. Stepwise multiple regression analysis showed that male sex, body height and weight, common IMT, plaque score, systolic blood pressure, and alcohol consumption were positively and independently related to lumen diameter. On the other hand, an independent negative association was observed between low-density lipoprotein cholesterol and lumen diameter.
Conclusions In 59- to 71-year-old subjects, increased IMT and atherosclerotic plaques were accompanied by an increase in lumen diameter of the common carotid arteries, indicating an overcompensation. Luminal enlargement observed with several risk factors and with high blood pressure in particular might be partially counteracted by high lipid levels.
Key Words: aging • carotid arteries • epidemiology • ultrasonics
This article has been cited by other articles:
 |
|
 |
|
  L. Ruan, W. Chen, S. R. Srinivasan, M. Sun, H. Wang, A. Toprak, and G. S. Berenson Correlates of Common Carotid Artery Lumen Diameter in Black and White Younger Adults: The Bogalusa Heart Study Stroke, March 1, 2009; 40(3): 702 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Paczek, W. Michalska, and I. Bartlomiejczyk Trypsin, elastase, plasmin and MMP-9 activity in the serum during the human ageing process Age Ageing, May 1, 2008; 37(3): 318 - 323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Dumont, M. Zureik, C. Bauters, M.-C. Grupposo, D. Cottel, M. Montaye, M. Hamon, P. Ducimetiere, P. Amouyel, and T. Brousseau Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2120 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. A. Korshunov, S. M. Schwartz, and B. C. Berk Vascular Remodeling: Hemodynamic and Biochemical Mechanisms Underlying Glagov's Phenomenon Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1722 - 1728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Makita, A. Ohira, Y. Naganuma, Y. Moriai, H. Niinuma, A. Abiko, and K. Hiramori Increased Carotid Artery Stiffness Without Atherosclerotic Change in Patients With Aortic Dissection Angiology, August 1, 2006; 57(4): 478 - 486. [Abstract] [PDF]
|
|
|
|
 |
|
 J. R. Crouse III Thematic review series: Patient-Oriented Research. Imaging atherosclerosis: state of the art J. Lipid Res., August 1, 2006; 47(8): 1677 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Krejza, M. Arkuszewski, S. E. Kasner, J. Weigele, A. Ustymowicz, R. W. Hurst, B. L. Cucchiara, and S. R. Messe Carotid Artery Diameter in Men and Women and the Relation to Body and Neck Size Stroke, April 1, 2006; 37(4): 1103 - 1105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. T. Akbaraly, J. Arnaud, I. Hininger-Favier, V. Gourlet, A.-M. Roussel, and C. Berr Selenium and Mortality in the Elderly: Results from the EVA Study Clin. Chem., November 1, 2005; 51(11): 2117 - 2123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Ostberg, A. E. Donald, J. P. J. Halcox, C. Storry, C. McCarthy, and G. S. Conway Vasculopathy in Turner Syndrome: Arterial Dilatation and Intimal Thickening without Endothelial Dysfunction J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5161 - 5166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Bots, D. E. Grobbee, A. Hofman, and J. C.M. Witteman Common Carotid Intima-Media Thickness and Risk of Acute Myocardial Infarction: The Role of Lumen Diameter Stroke, April 1, 2005; 36(4): 762 - 767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, J. Gariepy, D. Courbon, J.-F. Dartigues, K. Ritchie, C. Tzourio, A. Alperovitch, A. Simon, and P. Ducimetiere Alcohol Consumption and Carotid Artery Structure in Older French Adults: The Three-City Study Stroke, December 1, 2004; 35(12): 2770 - 2775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.L. Eigenbrodt, Z. Bursac, E.P. Eigenbrodt, D.J. Couper, R.E. Tracy, and J.L. Mehta Mathematical estimation of the potential effect of vascular remodelling/dilatation on B-mode ultrasound intima-medial thickness QJM, November 1, 2004; 97(11): 729 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M.A. Henry, P. J. Kostense, J. M. Dekker, G. Nijpels, R. J. Heine, O. Kamp, L. M. Bouter, and C. D.A. Stehouwer Carotid Arterial Remodeling: A Maladaptive Phenomenon in Type 2 Diabetes but Not in Impaired Glucose Metabolism: The Hoorn Study Stroke, March 1, 2004; 35(3): 671 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chironi, J. Gariepy, N. Denarie, M. Balice, J.-L. Megnien, J. Levenson, and A. Simon Influence of Hypertension on Early Carotid Artery Remodeling Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1460 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Terry, R. Tang, M. A. Espeland, D. H. Davis, J. L.C. Vieira, M. F. Mercuri, and J. R. Crouse III Carotid Arterial Structure in Patients With Documented Coronary Artery Disease and Disease-Free Control Subjects Circulation, March 4, 2003; 107(8): 1146 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Iannuzzi, M. De Michele, S. Panico, E. Celentano, R. Tang, M. G. Bond, L. Sacchetti, F. Zarrilli, R. Galasso, M. Mercuri, et al. Radical-Trapping Activity, Blood Pressure, and Carotid Enlargement in Women Hypertension, February 1, 2003; 41(2): 289 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Scuteri, C.-H. Chen, F. C.P. Yin, T. Chih-Tai, H. A. Spurgeon, and E. G. Lakatta Functional Correlates of Central Arterial Geometric Phenotypes Hypertension, December 1, 2001; 38(6): 1471 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. G.R. Schulz and P. M. Rothwell Major Variation in Carotid Bifurcation Anatomy: A Possible Risk Factor for Plaque Development? Stroke, November 1, 2001; 32(11): 2522 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mannami, S. Baba, and J. Ogata Potential of Carotid Enlargement as a Useful Indicator Affected by High Blood Pressure in a Large General Population of a Japanese City : The Suita Study Stroke, December 1, 2000; 31(12): 2958 - 2965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Jiang, K. Kohara, and K. Hiwada Association Between Risk Factors for Atherosclerosis and Mechanical Forces in Carotid Artery Stroke, October 1, 2000; 31(10): 2319 - 2324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gnasso, C. Motti, C. Irace, C. Carallo, L. Liberatoscioli, S. Bernardini, R. Massoud, P. L. Mattioli, G. Federici, and C. Cortese Genetic Variation in Human Stromelysin Gene Promoter and Common Carotid Geometry in Healthy Male Subjects Arterioscler. Thromb. Vasc. Biol., June 1, 2000; 20(6): 1600 - 1605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Bortolotto, O. Hanon, G. Franconi, P. Boutouyrie, S. Legrain, and X. Girerd The Aging Process Modifies the Distensibility of Elastic but not Muscular Arteries Hypertension, October 1, 1999; 34(4): 889 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Nagai, E J. Metter, and J. L Fleg Increased carotid artery intimal-medial thickness: risk factor for exercise-induced myocardial ischemia in asymptomatic older individuals Vascular Medicine, August 1, 1999; 4(3): 181 - 186. [Abstract] [PDF]
|
|
|
|
|
|
K. Jensen-Urstad, M. Jensen-Urstad, and J. Johansson Carotid Artery Diameter Correlates With Risk Factors for Cardiovascular Disease in a Population of 55-Year-Old Subjects Stroke, August 1, 1999; 30(8): 1572 - 1576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Carallo, C. Irace, A. Pujia, M. S. De Franceschi, A. Crescenzo, C. Motti, C. Cortese, P. L. Mattioli, and A. Gnasso Evaluation of Common Carotid Hemodynamic Forces : Relations With Wall Thickening Hypertension, August 1, 1999; 34(2): 217 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kiechl and J. Willeit The Natural Course of Atherosclerosis : Part II: Vascular Remodeling Arterioscler. Thromb. Vasc. Biol., June 1, 1999; 19(6): 1491 - 1498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pauletto, P. Palatini, S. Da Ros, V. Pagliara, N. Santipolo, S. Baccillieri, E. Casiglia, P. Mormino, and A. C. Pessina Factors Underlying the Increase in Carotid Intima-Media Thickness in Borderline Hypertensives Arterioscler. Thromb. Vasc. Biol., May 1, 1999; 19(5): 1231 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, P.-J. Touboul, C. Bonithon-Kopp, D. Courbon, I. Ruelland, and P. Ducimetiere Differential Association of Common Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaques With Parental History of Premature Death From Coronary Heart Disease : The EVA Study Arterioscler. Thromb. Vasc. Biol., February 1, 1999; 19(2): 366 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Demuth, N. Moatti, O. Hanon, M. O. Benoit, M. Safar, and X. Girerd Opposite Effects of Plasma Homocysteine and the Methylenetetrahydrofolate Reductase C677T Mutation on Carotid Artery Geometry in Asymptomatic Adults Arterioscler. Thromb. Vasc. Biol., December 1, 1998; 18(12): 1838 - 1843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nagai, E. J. Metter, C. J. Earley, M. K. Kemper, L. C. Becker, E. G. Lakatta, and J. L. Fleg Increased Carotid Artery Intimal-Medial Thickness in Asymptomatic Older Subjects With Exercise-Induced Myocardial Ischemia Circulation, October 13, 1998; 98(15): 1504 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rosfors, S. Hallerstam, K. Jensen-Urstad, M. Zetterling, and C. Carlstrom Relationship Between Intima-Media Thickness in the Common Carotid Artery and Atherosclerosis in the Carotid Bifurcation Stroke, July 1, 1998; 29(7): 1378 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gariepy, J. Salomon, N. Denarie, F. Laskri, J. L. Megnien, J. Levenson, and A. Simon Sex and Topographic Differences in Associations Between Large-Artery Wall Thickness and Coronary Risk Profile in a French Working Cohort : The AXA Study Arterioscler. Thromb. Vasc. Biol., April 1, 1998; 18(4): 584 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Bots, A. Hofman, and D. E. Grobbee Increased Common Carotid Intima-Media Thickness : Adaptive Response or a Reflection of Atherosclerosis? Findings From the Rotterdam Study Stroke, December 1, 1997; 28(12): 2442 - 2447. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Watanabe, T. Ishigami, Y. Kawano, T. Umahara, A. Nakamori, S. Mizushima, K. Hibi, I. Kobayashi, K. Tamura, H. Ochiai, et al. Angiotensin-Converting Enzyme Gene I/D Polymorphism and Carotid Plaques in Japanese Hypertension, September 1, 1997; 30(3): 569 - 573. [Abstract] [Full Text]
|
|
|
|
|
|
J. F. Polak, R. A. Kronmal, G. S. Tell, D. H. O'Leary, P. J. Savage, J. M. Gardin, G. H. Rutan, and N. O. Borhani Compensatory Increase in Common Carotid Artery Diameter: Relation to Blood Pressure and Artery Intima-Media Thickness in Older Adults Stroke, November 1, 1996; 27(11): 2012 - 2015. [Abstract] [Full Text]
|
|