(Stroke. 1996;27:833-837.)
© 1996 American Heart Association, Inc.
Articles |
Genetic Basis of Variation in Carotid Artery Wall Thickness
From the Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio (R.D., M.P.S.), and the Department of Genetics, Southwest Foundation for Biomedical Research (J.B.), San Antonio, Tex; the Centro de Estudios en Diabetes, The American British Cowdray Hospital, Unidad de Investigación Médica en Enfermedades Metabólicas, Hospital "Bernardo Sepulveda" Centro Medico Nacional, and Instituto Mexicano del Seguro Social, Mexico City, Mexico (C.G.V.); and the Department of Radiology, New England Medical Center, Tufts University School of Medicine, Boston, Mass (D.H.O'L.).
Correspondence to Ravindranath Duggirala, PhD, Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78284-7873. E-mail ravi@gauss.uthscsa.edu.
Background and Purpose Other than the documented associations of risk factors and carotid artery wall thickness, the genetic basis of variation in carotid artery intimal-medial thickness (IMT) is unknown. The purpose of this study was to examine the extent to which variation in common carotid artery (CCA) IMT and internal carotid artery (ICA) IMT are under genetic control.
Methods The sibship data used for this analysis were part of an epidemiological survey in Mexico City. The CCA and ICA analyses were based on 46 and 44 sibships of various sizes, respectively. The CCA and ICA IMTs were measured with carotid ultrasonography. Using a robust variance decomposition method, we performed genetic analyses of CCA IMT and ICA IMT measurements with models incorporating several cardiovascular risk factors (eg, lipids, diabetes, blood pressure, and smoking) as covariates.
Results After accounting for the effects of covariates, we detected high heritabilities for CCA IMT (h2=0.92±0.05, P=.001) and ICA IMT (h2=0.86±0.13, P=.029). Genes accounted for 66.0% of the total variation in CCA IMT, whereas 27.7% of variation was attributable to covariates. For ICA IMT, genes explained a high proportion (74.9%) of total phenotypic variation. The covariates accounted for 11.5% of variation in ICA IMT.
Conclusions Our results suggest that substantial proportions of phenotypic variance in CCA IMT and ICA IMT are attributable to shared genetic factors.
Key Words: carotid arteries • genetics • ultrasonics
This article has been cited by other articles:
 |
|
 |
|
  L. Paternoster, N. A. Martinez Gonzalez, S. Lewis, and C. Sudlow Association Between Apolipoprotein E Genotype and Carotid Intima-Media Thickness May Suggest a Specific Effect on Large Artery Atherothrombotic Stroke Stroke, January 1, 2008; 39(1): 48 - 54. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Murabito, C.-Y. Guo, C. S. Fox, and R. B. D'Agostino Heritability of the Ankle-Brachial Index: The Framingham Offspring Study Am. J. Epidemiol., November 15, 2006; 164(10): 963 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.A. Sayed-Tabatabaei, M.J.E. van Rijn, A.F.C. Schut, Y.S. Aulchenko, E.A. Croes, M.C. Zillikens, H.A.P. Pols, J.C.M. Witteman, B.A. Oostra, and C.M. van Duijn Heritability of the Function and Structure of the Arterial Wall: Findings of the Erasmus Rucphen Family (ERF) Study Stroke, November 1, 2005; 36(11): 2351 - 2356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Mayosi, P. J. Avery, M. Baker, N. Gaukrodger, H. Imrie, F. R. Green, M. Farrall, H. Watkins, and B. Keavney Genotype at the -174G/C Polymorphism of the Interleukin-6 Gene Is Associated With Common Carotid Artery Intimal-Medial Thickness: Family Study and Meta-Analysis Stroke, October 1, 2005; 36(10): 2215 - 2219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.H. L. Kao, W.-C. Hsueh, D. L. Rainwater, D. H. O'Leary, I. G. Imumorin, M. P. Stern, and B. D. Mitchell Family History of Type 2 Diabetes Is Associated With Increased Carotid Artery Intimal-Medial Thickness in Mexican Americans Diabetes Care, August 1, 2005; 28(8): 1882 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Moskau, A. Golla, C. Grothe, M. Boes, C. Pohl, and T. Klockgether Heritability of Carotid Artery Atherosclerotic Lesions: An Ultrasound Study in 154 Families Stroke, January 1, 2005; 36(1): 5 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. H. Juo, H.-F. Lin, T. Rundek, E. A. Sabala, B. Boden-Albala, N. Park, M.-Y. Lan, and R. L. Sacco Genetic and Environmental Contributions to Carotid Intima-Media Thickness and Obesity Phenotypes in the Northern Manhattan Family Study Stroke, October 1, 2004; 35(10): 2243 - 2247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Manolio, E. Boerwinkle, C. J. O'Donnell, and A. F. Wilson Genetics of Ultrasonographic Carotid Atherosclerosis Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1567 - 1577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Smith Jr, R. V. Milani, D. K. Arnett, J. R. Crouse III, M. M. McDermott, P. M Ridker, R. S. Rosenson, K. A. Taubert, and P. W.F. Wilson Atherosclerotic Vascular Disease Conference: Writing Group II: Risk Factors Circulation, June 1, 2004; 109(21): 2613 - 2616. [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Li, I. Kamel, F. Rando, M. Anderson, B. Kumbasar, J. A. C. Lima, and D. A. Bluemke Using MRI to Assess Aortic Wall Thickness in the Multiethnic Study of Atherosclerosis: Distribution by Race, Sex, and Age Am. J. Roentgenol., March 1, 2004; 182(3): 593 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Risley, P. Jerrard-Dunne, M. Sitzer, A. Buehler, S. von Kegler, and H. S. Markus Promoter Polymorphism in the Endotoxin Receptor (CD14) Is Associated With Increased Carotid Atherosclerosis Only in Smokers: The Carotid Atherosclerosis Progression Study (CAPS) Stroke, March 1, 2003; 34(3): 600 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. North, B. V. Howard, T. K. Welty, L. G. Best, E. T. Lee, J. L. Yeh, R. R. Fabsitz, M. J. Roman, and J. W. MacCluer Genetic and Environmental Contributions to Cardiovascular Disease Risk in American Indians: The Strong Heart Family Study Am. J. Epidemiol., February 15, 2003; 157(4): 303 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jerrard-Dunne, H. S. Markus, D. A. Steckel, A. Buehler, S. von Kegler, and M. Sitzer Early Carotid Atherosclerosis and Family History of Vascular Disease: Specific Effects on Arterial Sites Have Implications for Genetic Studies Arterioscler. Thromb. Vasc. Biol., February 1, 2003; 23(2): 302 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Fox, J. F. Polak, I. Chazaro, A. Cupples, P. A. Wolf, R. A. D'Agostino, and C. J. O'Donnell Genetic and Environmental Contributions to Atherosclerosis Phenotypes in Men and Women: Heritability of Carotid Intima-Media Thickness in the Framingham Heart Study Stroke, February 1, 2003; 34(2): 397 - 401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Jerrard-Dunne, M. Sitzer, P. Risley, D. A. Steckel, A. Buehler, S. von Kegler, and H. S. Markus Interleukin-6 Promoter Polymorphism Modulates the Effects of Heavy Alcohol Consumption on Early Carotid Artery Atherosclerosis: The Carotid Atherosclerosis Progression Study (CAPS) Stroke, February 1, 2003; 34(2): 402 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Hunt, R. Duggirala, H. H.H. Goring, J. T. Williams, L. Almasy, J. Blangero, D. H. O'Leary, and M. P. Stern Genetic Basis of Variation in Carotid Artery Plaque in the San Antonio Family Heart Study Stroke, December 1, 2002; 33(12): 2775 - 2780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. North, J. W. MacCluer, R. B. Devereux, B. V. Howard, T. K. Welty, L. G. Best, E. T. Lee, R. R. Fabsitz, and M. J. Roman Heritability of Carotid Artery Structure and Function: The Strong Heart Family Study Arterioscler. Thromb. Vasc. Biol., October 1, 2002; 22(10): 1698 - 1703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Kuhel, B. Zhu, D. P. Witte, and D. Y. Hui Distinction in Genetic Determinants for Injury-Induced Neointimal Hyperplasia and Diet-Induced Atherosclerosis in Inbred Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2002; 22(6): 955 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Xiang, S. P. Azen, T. A. Buchanan, L. J. Raffel, S. Tan, L.S.-C. Cheng, J. Diaz, E. Toscano, M. Quinonnes, C.R. Liu, et al. Heritability of Subclinical Atherosclerosis in Latino Families Ascertained Through a Hypertensive Parent Arterioscler. Thromb. Vasc. Biol., May 1, 2002; 22(5): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Markus, Z. Kapozsta, R. Ditrich, C. Wolfe, N. Ali, J. Powell, M. Mendell, and M. Cullinane Increased Common Carotid Intima-Media Thickness in UK African Caribbeans and Its Relation to Chronic Inflammation and Vascular Candidate Gene Polymorphisms Stroke, November 1, 2001; 32(11): 2465 - 2471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Wagenknecht, D. W. Bowden, J. J. Carr, C. D. Langefeld, B. I. Freedman, and S. S. Rich Familial Aggregation of Coronary Artery Calcium in Families With Type 2 Diabetes Diabetes, April 1, 2001; 50(4): 861 - 866. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Hassan and H. S. Markus Genetics and ischaemic stroke Brain, September 1, 2000; 123(9): 1784 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. S. Woo, P. Chook, O. T. Raitakari, B. McQuillan, J. Z. Feng, and D. S. Celermajer Westernization of Chinese Adults and Increased Subclinical Atherosclerosis Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2487 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Assadnia, J. P. Rapp, A. L. Nestor, T. Pringle, G. J. Cerilli, W. T. Gunning III, T. H. Webb, M. Kligman, and D. C. Allison Strain Differences in Neointimal Hyperplasia in the Rat Circ. Res., June 11, 1999; 84(11): 1252 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ebrahim, O. Papacosta, P. Whincup, G. Wannamethee, M. Walker, A. N. Nicolaides, S. Dhanjil, M. Griffin, G. Belcaro, A. Rumley, et al. Carotid Plaque, Intima Media Thickness, Cardiovascular Risk Factors, and Prevalent Cardiovascular Disease in Men and Women : The British Regional Heart Study Stroke, April 1, 1999; 30(4): 841 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Sacco, J. K. Roberts, B. Boden-Albala, Q. Gu, I-F. Lin, D. E. Kargman, L. Berglund, W. A. Hauser, S. Shea, and M. C. Paik Race-Ethnicity and Determinants of Carotid Atherosclerosis in a Multiethnic Population : The Northern Manhattan Stroke Study Stroke, May 1, 1997; 28(5): 929 - 935. [Abstract] [Full Text]
|
|