This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by van Kooten, F. Articles by Koudstaal, P. J. Search for Related Content PubMed PubMed Citation Articles by van Kooten, F. Articles by Koudstaal, P. J. Pubmed/NCBI databases Substance via MeSH

(Stroke. 1996;27:1231-1235.)
© 1996 American Heart Association, Inc.

Articles

Lipoprotein(a) in Patients With Acute Cerebral Ischemia

Fop van Kooten, MD; Johannes van Krimpen, MD; Diederik W.J. Dippel, MD; Nicoline Hoogerbrugge, MD Peter J. Koudstaal, MD

the Departments of Neurology (F. van Kooten, J. van Krimpen, D.W.J.D, P.J.K.) and Internal Medicine III (N.H.), University Hospital Rotterdam Dijkzigt, the Netherlands.

Correspondence to Fop van Kooten, MD, Department of Neurology, University Hospital Rotterdam Dijkzigt, 40 Dr Molewaterplein, 3015 GD Rotterdam, Netherlands. E-mail vanKooten@neuro.fgg.eur.nl.

Background and Purpose In several cross-sectional studies, a high serum lipoprotein(a) [Lp(a)] level was found to be an independent risk factor for cerebral infarction. In a recent prospective study, however, no association was found between Lp(a) levels at baseline and future risk of stroke. Whether Lp(a) is a prognostic factor in a high-risk population of patients with acute ischemic stroke remains unclear.

Methods We assessed Lp(a) level on admission to study its relationship with cardiovascular risk profile, stroke severity, and prognosis in 151 consecutive patients with acute cerebral ischemia. The mean follow-up period was 2.5±1.2 years. Lp(a) was measured by means of a solid-phase two-site immunoradiometric assay.

Results Increased Lp(a) levels were found in 53 (35%) of the patients with cerebral ischemia. Median (5th and 95th percentile) values of Lp(a) were 191 (12 and 1539) mg/L and 197 (10 and 1255) mg/L for patients with transient ischemic attack and patients with ischemic stroke, respectively. No relationship was found between Lp(a) levels and stroke severity (P=.68) or the occurrence of vascular events during follow-up (P log rank=0.81).

Conclusions We conclude that Lp(a) is increased in about one third of patients with acute cerebral ischemia, but it does not appear to be associated with the cardiovascular risk profile, stroke characteristics, or the prognosis of such patients.

Key Words: cerebral ischemia • lipoproteins • prognosis

This article has been cited by other articles:

				B. Smolders, R. Lemmens, and V. Thijs Lipoprotein (a) and Stroke: A Meta-Analysis of Observational Studies Stroke, June 1, 2007; 38(6): 1959 - 1966. [Abstract] [Full Text] [PDF]

				E. Zambrelli, E. Emanuele, S. Marcheselli, L. Montagna, D. Geroldi, and G. Micieli Apo(a) size in ischemic stroke: Relation with subtype and severity on hospital admission Neurology, April 26, 2005; 64(8): 1366 - 1370. [Abstract] [Full Text] [PDF]

				K.-L. Chien, F.-C. Sung, H.-C. Hsu, T.-C. Su, R.-S. Lin, and Y.-T. Lee Apolipoprotein A-I and B and Stroke Events in a Community-Based Cohort in Taiwan: Report of the Chin-Shan Community Cardiovascular Study Stroke, January 1, 2002; 33(1): 39 - 44. [Abstract] [Full Text] [PDF]

				H. J Milionis, A. F Winder, and D. P Mikhailidis Lipoprotein (a) and stroke J. Clin. Pathol., July 1, 2000; 53(7): 487 - 496. [Abstract] [Full Text] [PDF]

				K. J. Harjai Potential New Cardiovascular Risk Factors: Left Ventricular Hypertrophy, Homocysteine, Lipoprotein(a), Triglycerides, Oxidative Stress, and Fibrinogen Ann Intern Med, September 7, 1999; 131(5): 376 - 386. [Abstract] [Full Text] [PDF]