This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pauletto, P. Articles by Palu, G. Search for Related Content PubMed PubMed Citation Articles by Pauletto, P. Articles by Palu, G.

(Stroke. 1996;27:1669-1671.)
© 1996 American Heart Association, Inc.

Articles

Human Cytomegalovirus and Restenosis of the Internal Carotid Artery

Paolo Pauletto, MD; Guglielmo Pisoni, MD; Roberta Boschetto, MD; Miranda Zoleo, MD; Achille C. Pessina, MD, PhD Giorgio Palu, MD

the Istituto di Medicina Clinica (P.P., M.Z., A.C.P.) and the Istituto di Microbiologia (G. Pisoni, R.B., G. Palu), Universita di Padova (Italy).

Correspondence to Paolo Pauletto, MD, Associate Professor, Istituto di Medicina Clinica, Universita di Padova, Via Giustiniani, 2, 35126 Padova, Italy. E-mail pauletto@ipdunidix.unipd.it.

Background Although human cytomegalovirus (HCMV) has been implicated in coronary restenosis, data on the presence of HCMV in the restenosis lesion of the internal carotid artery (ICA) are lacking.

Summary of Report We studied endarterectomy tissue from 5 ICA restenoses and 5 primary atherosclerotic lesions and tissue from 5 normal ICAs. The extracted DNA was tested for HCMV sequences with polymerase chain reaction by use of three primer pairs that amplify different genomic regions. The AD169 strain of HCMV served as the positive control. No trace of the HCMV genome was found in the intima or in the underlying media of endarterectomy specimens from restenosis and primary lesions. The media from control arteries was also HCMV negative.

Conclusions At variance with previous studies carried out in coronary arteries, our results do not support the hypothesis that HCMV infection is implicated in restenosis of the ICA.

Key Words: atherosclerosis • carotid artery diseases • carotid endarterectomy • risk factors

This article has been cited by other articles:

				T. Maisch, B. Kropff, C. Sinzger, and M. Mach Upregulation of CD40 Expression on Endothelial Cells Infected with Human Cytomegalovirus J. Virol., November 13, 2002; 76(24): 12803 - 12812. [Abstract] [Full Text] [PDF]

				R. M. Presti, J. L. Pollock, A. J. Dal Canto, A. K. O'Guin, and H. W. Virgin IV Interferon gamma  Regulates Acute and Latent Murine Cytomegalovirus Infection and Chronic Disease of the Great Vessels J. Exp. Med., August 3, 1998; 188(3): 577 - 588. [Abstract] [Full Text] [PDF]