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(Stroke. 1997;28:1-5.)
© 1997 American Heart Association, Inc.

Articles

Early Hemorrhage Growth in Patients With Intracerebral Hemorrhage

Thomas Brott, MD; Joseph Broderick, MD; Rashmi Kothari, MD; William Barsan, MD; Thomas Tomsick, MD; Laura Sauerbeck, RN; Judith Spilker, RN; John Duldner, MD Jane Khoury, MS

the University of Cincinnati (Ohio) Medical Center (T.B., J.B., R.K., T.T., L.S., J.S., J.K.); University of Michigan Medical Center, Ann Arbor (W.B.); and MetroHealth Medical Center, Cleveland, Ohio (J.D.).

Background and Purpose The goal of the present study was to prospectively determine how frequently early growth of intracerebral hemorrhage occurs and whether this early growth is related to early neurological deterioration.

Methods We performed a prospective observational study of patients with intracerebral hemorrhage within 3 hours of onset. Patients had a neurological evaluation and CT scan performed at baseline, 1 hour after baseline, and 20 hours after baseline.

Results Substantial growth in the volume of parenchymal hemorrhage occurred in 26% of the 103 study patients between the baseline and 1-hour CT scans. An additional 12% of patients had substantial growth between the 1- and 20-hour CT scans. Hemorrhage growth between the baseline and 1-hour CT scans was significantly associated with clinical deterioration, as measured by the change between the baseline and 1-hour Glasgow Coma Scale and National Institutes of Health Stroke Scale scores. No baseline clinical or CT prediction of hemorrhage growth was identified.

Conclusions Substantial early hemorrhage growth in patients with intracerebral hemorrhage is common and is associated with neurological deterioration. Randomized treatment trials are needed to determine whether this early natural history of ongoing bleeding and frequent neurological deterioration can be improved.


Key Words: computed tomography • intracerebral hemorrhage • prognosis




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