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(Stroke. 1997;28:2084-2093.)
© 1997 American Heart Association, Inc.
Articles |
Symptomatic Carotid Artery Occlusion
A Reappraisal of Hemodynamic Factors
From the University Departments of Neurology (C.J.M.K., L.J.K., J. van G.) and Neurosurgery (C.A.F.T.), University Hospital Utrecht (Netherlands).
Correspondence to C.J.M. Klijn, MD, University Department of Neurology, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, Netherlands. E-mail cklijn{at}neuro.azu.nl.
Background Over the last several years evidence has accumulated that in addition to embolism, a compromised cerebral blood flow may play an important role in causing transient ischemic attacks and ischemic stroke in patients with occlusion of the internal carotid artery. This evidence is found in both clinical features and ancillary investigations, particularly measurements of cerebral blood flow.
Summary of Review On the basis of 20 follow-up studies in patients with transient ischemic attacks or minor ischemic stroke associated with an occluded carotid artery, the annual risk of stroke was 5.5% (95% confidence interval [CI], 5.0% to 6.0%), and that of ipsilateral stroke (distinguished in 11 of the 20 studies) was 2.1% (95% CI, 1.6% to 2.8%). Patients with a compromised cerebral blood flow as measured by positron emission tomography, single-photon emission CT, transcranial Doppler, or stable xenon CT (six studies) have an even higher annual risk of stroke (all strokes: 12.5%; 95% CI, 8.9% to 17.6%; ipsilateral stroke: 9.5%; 95% CI, 6.4% to 14.0%).
Conclusions Because a compromised cerebral blood flow may be an important causal factor in patients with symptomatic carotid artery occlusion, medical and surgical options for treatment are reviewed in this light.
Key Words: carotid artery occlusion • cerebral ischemia • hemodynamics • outcome
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
L. R. Caplan and M. Hennerici Impaired Clearance of Emboli (Washout) Is an Important Link Between Hypoperfusion, Embolism, and Ischemic Stroke Arch Neurol, November 1, 1998; 55(11): 1475 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Grubb Jr, C. P. Derdeyn, S. M. Fritsch, D. A. Carpenter, K. D. Yundt, T. O. Videen, E. L. Spitznagel, and W. J. Powers Importance of Hemodynamic Factors in the Prognosis of Symptomatic Carotid Occlusion JAMA, September 23, 1998; 280(12): 1055 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Adams Jr Occlusion of the Internal Carotid Artery: Reopening a Closed Door? JAMA, September 23, 1998; 280(12): 1093 - 1094. [Full Text] [PDF]
|
|
|
|
|
|
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|
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|
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