Donate Help Contact The AHA Sign In Home
American Heart Association
Stroke
Search: search_blue_button Advanced Search
Table of Contents | Next Article »
Stroke. 1997;28:2109-2118

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Group, T. N. t-P. S. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Group, T. N. t-P. S. S.

(Stroke. 1997;28:2109-2118.)
© 1997 American Heart Association, Inc.

Articles

Intracerebral Hemorrhage After Intravenous t-PA Therapy for Ischemic Stroke

The NINDS t-PA Stroke Study Group
Background and Purpose We sought to identify variables associated with intracerebral hemorrhage in patients with acute ischemic stroke who receive tissue plasminogen activator (t-PA).

Methods We performed subgroup analyses of data from a randomized, double-blind, placebo-controlled trial of intravenous t-PA administered to stroke patients within 3 hours of onset. Using multivariable regression modeling procedures, we assessed the relationship of baseline and after-treatment variables with symptomatic and asymptomatic intracerebral hemorrhage during the first 36 hours after treatment.

Results Overall, t-PA–treated patients had an increase in the absolute risk of symptomatic intracerebral hemorrhage of 6% and a decrease in the absolute risk of 3-month mortality of 4% compared with placebo-treated patients. The only variables independently associated with an increased risk of symptomatic intracerebral hemorrhage in the final multivariable logistic regression model for the 312 t-PA–treated patients were the severity of neurological deficit as measured by the National Institutes of Health Stroke Scale score (five categories; odds ratio [OR], 1.8; 95% confidence interval [CI], 1.2 to 2.9) and brain edema (defined as acute hypodensity) or mass effect by CT before treatment (OR, 7.8; 95% CI, 2.2 to 27.1). This final model correctly predicted those t-PA–treated patients who would or would not have a symptomatic hemorrhage with only 57% efficiency. In the subgroup of patients with a severe neurological deficit, t-PA–treated patients were more likely than placebo-treated patients to have a favorable 3-month outcome (adjusted OR based on multiple outcomes, 4.3; 95% CI, 1.6 to 11.9). These results were similar for the subgroup with edema or mass effect by CT (adjusted OR, 3.4; 95% CI, 0.6 to 20.7). The likelihood of severe disability or death was similar for t-PA–and placebo-treated patients with these two baseline characteristics.

Conclusions Despite a higher rate of intracerebral hemorrhage, patients with severe strokes or edema or mass effect on the baseline CT are reasonable candidates for t-PA, if it is administered within 3 hours of onset.


Key Words: cerebral ischemia • computed tomography • thrombolytic therapy • clinical trials • intracerebral hemorrhage




This article has been cited by other articles:


Home page
 StrokeHome page
C. E. Lovelock, P. Anslow, A. J. Molyneux, J. V. Byrne, W. Kuker, P. M. Pretorius, A. Coull, and P. M. Rothwell
Substantial Observer Variability in the Differentiation Between Primary Intracerebral Hemorrhage and Hemorrhagic Transformation of Infarction on CT Brain Imaging
Stroke, December 1, 2009; 40(12): 3763 - 3767.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver, and D.J. Mikulis
Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study
AJNR Am. J. Neuroradiol., November 1, 2009; 30(10): 1864 - 1869.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
A. A. Mazumder and G. A. Pope
Stroke quiz
BMJ, September 2, 2009; 339(sep02_2): b3343 - b3343.
[Full Text]

Home page
 StrokeHome page
B. Cucchiara, S. E. Kasner, D. Tanne, S. R. Levine, A. Demchuk, S. R. Messe, L. Sansing, K. R. Lees, P. Lyden, and for the SAINT Investigators
Factors Associated With Intracerebral Hemorrhage After Thrombolytic Therapy for Ischemic Stroke: Pooled Analysis of Placebo Data From the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials
Stroke, September 1, 2009; 40(9): 3067 - 3072.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. Summers, A. Leonard, D. Wentworth, J. L. Saver, J. Simpson, J. A. Spilker, N. Hock, E. Miller, P. H. Mitchell, and on behalf of the American Heart Association Counci
Comprehensive Overview of Nursing and Interdisciplinary Care of the Acute Ischemic Stroke Patient: A Scientific Statement From the American Heart Association
Stroke, August 1, 2009; 40(8): 2911 - 2944.
[Full Text] [PDF]

Home page
 Journal of NeuroInterventional SurgeryHome page
R Novakovic, G Toth, and P D Purdy
Review of current and emerging therapies in acute ischemic stroke
JNIS, July 1, 2009; 1(1): 13 - 26.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
N. Ahmed, N. Wahlgren, M. Brainin, J. Castillo, G. A. Ford, M. Kaste, K. R. Lees, D. Toni, and for the SITS Investigators
Relationship of Blood Pressure, Antihypertensive Therapy, and Outcome in Ischemic Stroke Treated With Intravenous Thrombolysis: Retrospective Analysis From Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR)
Stroke, July 1, 2009; 40(7): 2442 - 2449.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
R. I. Aviv, C. D. d'Esterre, B. D. Murphy, J. J. Hopyan, B. Buck, G. Mallia, V. Li, L. Zhang, S. P. Symons, and T.-Y. Lee
Hemorrhagic Transformation of Ischemic Stroke: Prediction with CT Perfusion
Radiology, March 1, 2009; 250(3): 867 - 877.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
G. Tsagalis, T. Akrivos, M. Alevizaki, E. Manios, M. Theodorakis, A. Laggouranis, and K. N. Vemmos
Long-Term Prognosis of Acute Kidney Injury after First Acute Stroke
Clin. J. Am. Soc. Nephrol., March 1, 2009; 4(3): 616 - 622.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. P. Broderick
Endovascular Therapy for Acute Ischemic Stroke
Stroke, March 1, 2009; 40(3_suppl_1): S103 - S106.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
O. Y. Bang, J. L. Saver, J. R. Alger, S. H. Shah, B. H. Buck, S. Starkman, B. Ovbiagele, D. S. Liebeskind, and for the UCLA MRI Permeability Investigators
Patterns and Predictors of Blood-Brain Barrier Permeability Derangements in Acute Ischemic Stroke
Stroke, February 1, 2009; 40(2): 454 - 461.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
G. Tsagalis, T. Akrivos, M. Alevizaki, E. Manios, K. Stamatellopoulos, A. Laggouranis, and K. N. Vemmos
Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality
Nephrol. Dial. Transplant., January 1, 2009; 24(1): 194 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
G.A. Christoforidis, C. Karakasis, Y. Mohammad, L.P. Caragine, M. Yang, and A.P. Slivka
Predictors of Hemorrhage Following Intra-Arterial Thrombolysis for Acute Ischemic Stroke: The Role of Pial Collateral Formation
AJNR Am. J. Neuroradiol., January 1, 2009; 30(1): 165 - 170.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. J. Alberts, R. A. Felberg, L. R. Guterman, S. R. Levine, and for Writing Group 4
Atherosclerotic Peripheral Vascular Disease Symposium II: Stroke Intervention: State of the Art
Circulation, December 16, 2008; 118(25): 2845 - 2851.
[Full Text] [PDF]

Home page
 StrokeHome page
N. Wahlgren, N. Ahmed, N. Eriksson, F. Aichner, E. Bluhmki, A. Davalos, T. Erila, G. A. Ford, M. Grond, W. Hacke, et al.
Multivariable Analysis of Outcome Predictors and Adjustment of Main Outcome Results to Baseline Data Profile in Randomized Controlled Trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST)
Stroke, December 1, 2008; 39(12): 3316 - 3322.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
Y. Murata, A. Rosell, R. H. Scannevin, K. J. Rhodes, X. Wang, and E. H. Lo
Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke
Stroke, December 1, 2008; 39(12): 3372 - 3377.
[Abstract] [Full Text] [PDF]

Home page
 BMJ Case ReportsHome page
K. B. Slot, E. Berge, and J. Wardlaw
Haemorrhagic transformation of a recent silent cerebral infarct during thrombolytic stroke treatment
BMJ Case Reports, November 20, 2008; 2008(nov12_1): bcr0620080266 - bcr0620080266.
[Abstract] [Full Text]

Home page
 NeurologyHome page
M. Lou, A. Safdar, M. Mehdiratta, S. Kumar, G. Schlaug, L. Caplan, D. Searls, and M. Selim
The HAT Score: A simple grading scale for predicting hemorrhage after thrombolysis
Neurology, October 28, 2008; 71(18): 1417 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Saqqur, G. Tsivgoulis, C. A. Molina, A. M. Demchuk, M. Siddiqui, J. Alvarez-Sabin, K. Uchino, S. Calleja, A. V. Alexandrov, and For the CLOTBUST Investigators
Symptomatic intracerebral hemorrhage and recanalization after IV rt-PA: A multicenter study
Neurology, October 21, 2008; 71(17): 1304 - 1312.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Derex and N Nighoghossian
Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: an update
J. Neurol. Neurosurg. Psychiatry, October 1, 2008; 79(10): 1093 - 1099.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
W. Hacke, M. Kaste, E. Bluhmki, M. Brozman, A. Davalos, D. Guidetti, V. Larrue, K. R. Lees, Z. Medeghri, T. Machnig, et al.
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
N. Engl. J. Med., September 25, 2008; 359(13): 1317 - 1329.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. T. Whelan, J. D. Cook, C. M. Amlie-Lefond, C. A. Hovinga, A. K. Chan, R. N. Ichord, G. A. deVeber, and P. F. Thall
Practical Model-Based Dose Finding in Early-Phase Clinical Trials: Optimizing Tissue Plasminogen Activator Dose for Treatment of Ischemic Stroke in Children
Stroke, September 1, 2008; 39(9): 2627 - 2636.
[Abstract] [Full Text] [PDF]

Home page
 Clin TrialsHome page
V. Hertzberg, T. Ingall, W. O'Fallon, K. Asplund, L. Goldfrank, T. Louis, and T. Christianson
Methods and processes for the reanalysis of the NINDS tissue plasminogen activator for acute ischemic stroke treatment trial
Clinical Trials, August 1, 2008; 5(4): 308 - 315.
[Abstract] [PDF]

Home page
 Emerg. Med. J.Home page
A Semplicini, V Benetton, L Macchini, A Realdi, R Manara, C Carollo, E Parotto, V Mascagna, M Leoni, L A Calo, et al.
Intravenous thrombolysis in the emergency department for the treatment of acute ischaemic stroke
Emerg. Med. J., July 1, 2008; 25(7): 403 - 406.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
B R Thanvi, S Treadwell, and T Robinson
Haemorrhagic transformation in acute ischaemic stroke following thrombolysis therapy: classification, pathogenesis and risk factors
Postgrad. Med. J., July 1, 2008; 84(993): 361 - 367.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Cardiovasc DisHome page
M. Collino, N. S.A. Patel, and C. Thiemermann
Review: PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury
Therapeutic Advances in Cardiovascular Disease, June 1, 2008; 2(3): 179 - 197.
[Abstract] [PDF]

Home page
 ChestHome page
S. Schulman, R. J. Beyth, C. Kearon, and M. N. Levine
Hemorrhagic Complications of Anticoagulant and Thrombolytic Treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
Chest, June 1, 2008; 133(6_suppl): 257S - 298S.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
H. Hallevi and J. C. Grotta
Antiplatelet Therapy and the Risk of Intracranial Hemorrhage After Intravenous Tissue Plasminogen Activator Therapy for Acute Ischemic Stroke
Arch Neurol, May 1, 2008; 65(5): 575 - 576.
[Full Text] [PDF]

Home page
 Arch NeurolHome page
M. Uyttenboogaart, M. W. Koch, K. Koopman, P. C. A. J. Vroomen, J. De Keyser, and G.-J. Luijckx
Safety of Antiplatelet Therapy Prior to Intravenous Thrombolysis in Acute Ischemic Stroke
Arch Neurol, May 1, 2008; 65(5): 607 - 611.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M.-F. Ritz, P. Ratajczak, Y. Curin, E. Cam, A. Mendelowitsch, F. Pinet, and R. Andriantsitohaina
Chronic Treatment with Red Wine Polyphenol Compounds Mediates Neuroprotection in a Rat Model of Ischemic Cerebral Stroke
J. Nutr., March 1, 2008; 138(3): 519 - 525.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. P. Adams Jr, M. B. Effron, J. Torner, A. Davalos, J. Frayne, P. Teal, J. Leclerc, B. Oemar, L. Padgett, E. S. Barnathan, et al.
Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of an International Phase III Trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II)
Stroke, January 1, 2008; 39(1): 87 - 99.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Broderick, S. Connolly, E. Feldmann, D. Hanley, C. Kase, D. Krieger, M. Mayberg, L. Morgenstern, C. S. Ogilvy, P. Vespa, et al.
REPRINT: Guidelines for the Management of Spontaneous Intracerebral Hemorrhage in Adults: 2007 Update: A Guideline From the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
Circulation, October 16, 2007; 116(16): e391 - e413.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. De Keyser, Z. Gdovinova, M. Uyttenboogaart, P. C. Vroomen, and G. J. Luijckx
Intravenous Alteplase for Stroke: Beyond the Guidelines and in Particular Clinical Situations
Stroke, September 1, 2007; 38(9): 2612 - 2618.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
C. Foerch, M. T. Wunderlich, F. Dvorak, M. Humpich, T. Kahles, M. Goertler, J. Alvarez-Sabin, C. W. Wallesch, C. A. Molina, H. Steinmetz, et al.
Elevated Serum S100B Levels Indicate a Higher Risk of Hemorrhagic Transformation After Thrombolytic Therapy in Acute Stroke
Stroke, September 1, 2007; 38(9): 2491 - 2495.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. G. Lansberg, V. N. Thijs, R. Bammer, S. Kemp, C. A.C. Wijman, M. P. Marks, G. W. Albers, and on behalf of the DEFUSE Investigators
Risk Factors of Symptomatic Intracerebral Hemorrhage After tPA Therapy for Acute Stroke
Stroke, August 1, 2007; 38(8): 2275 - 2278.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. L. Saver
Hemorrhage After Thrombolytic Therapy for Stroke: The Clinically Relevant Number Needed to Harm
Stroke, August 1, 2007; 38(8): 2279 - 2283.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
The IMS II Trial Investigators
The Interventional Management of Stroke (IMS) II Study
Stroke, July 1, 2007; 38(7): 2127 - 2135.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
G. A. Christoforidis, A. Slivka, Y. Mohammad, C. Karakasis, B. Avutu, and M. Yang
Size Matters: Hemorrhage Volume as an Objective Measure to Define Significant Intracranial Hemorrhage Associated With Thrombolysis
Stroke, June 1, 2007; 38(6): 1799 - 1804.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Broderick, S. Connolly, E. Feldmann, D. Hanley, C. Kase, D. Krieger, M. Mayberg, L. Morgenstern, C. S. Ogilvy, P. Vespa, et al.
Guidelines for the Management of Spontaneous Intracerebral Hemorrhage in Adults: 2007 Update: A Guideline From the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
Stroke, June 1, 2007; 38(6): 2001 - 2023.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. P. Adams Jr, G. del Zoppo, M. J. Alberts, D. L. Bhatt, L. Brass, A. Furlan, R. L. Grubb, R. T. Higashida, E. C. Jauch, C. Kidwell, et al.
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
Circulation, May 22, 2007; 115(20): e478 - e534.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. P. Adams Jr, G. del Zoppo, M. J. Alberts, D. L. Bhatt, L. Brass, A. Furlan, R. L. Grubb, R. T. Higashida, E. C. Jauch, C. Kidwell, et al.
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Stroke, May 1, 2007; 38(5): 1655 - 1711.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
O. Y. Bang, J. L. Saver, D. S. Liebeskind, S. Starkman, P. Villablanca, N. Salamon, B. Buck, L. Ali, L. Restrepo, F. Vinuela, et al.
Cholesterol level and symptomatic hemorrhagic transformation after ischemic stroke thrombolysis
Neurology, March 6, 2007; 68(10): 737 - 742.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C Brekenfeld, L Remonda, K Nedeltchev, M Arnold, H P Mattle, U Fischer, L Kappeler, and G Schroth
Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase
J. Neurol. Neurosurg. Psychiatry, March 1, 2007; 78(3): 280 - 285.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
G. Thomalla, J. Sobesky, M. Kohrmann, J. B. Fiebach, J. Fiehler, O. Zaro Weber, A. Kruetzelmann, T. Kucinski, M. Rosenkranz, J. Rother, et al.
Two Tales: Hemorrhagic Transformation but Not Parenchymal Hemorrhage After Thrombolysis Is Related to Severity and Duration of Ischemia: MRI Study of Acute Stroke Patients Treated With Intravenous Tissue Plasminogen Activator Within 6 Hours
Stroke, February 1, 2007; 38(2): 313 - 318.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. Khatri, L. R. Wechsler, and J. P. Broderick
Intracranial Hemorrhage Associated With Revascularization Therapies
Stroke, February 1, 2007; 38(2): 431 - 440.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
B. M. Demaerschalk
The Stroke-Thrombolytic Predictive Instrument Provides Valid Quantitative Estimates of Outcome Probabilities and Aids Clinical Decision-Making
Stroke, December 1, 2006; 37(12): 2865 - 2866.
[Full Text] [PDF]

Home page
 Age AgeingHome page
S. T. Engelter, L. H. Bonati, and P. A. Lyrer
Intravenous thrombolysis in stroke patients of >=80 versus <80 years of age--a systematic review across cohort studies.
Age Ageing, November 1, 2006; 35(6): 572 - 580.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
K. Z. Bambauer, S. C. Johnston, D. E. Bambauer, and J. A. Zivin
Nonstroke Treatment--Reply
Arch Neurol, October 1, 2006; 63(10): 1506 - 1507.
[Full Text] [PDF]

Home page
 StrokeHome page
T. Neumann-Haefelin, S. Hoelig, J. Berkefeld, J. Fiehler, A. Gass, M. Humpich, A. Kastrup, T. Kucinski, O. Lecei, D. S. Liebeskind, et al.
Leukoaraiosis Is a Risk Factor for Symptomatic Intracerebral Hemorrhage After Thrombolysis for Acute Stroke
Stroke, October 1, 2006; 37(10): 2463 - 2466.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
R. Gupta, H. Yonas, J. Gebel, S. Goldstein, M. Horowitz, S. Z. Grahovac, L. R. Wechsler, M. D. Hammer, K. Uchino, and T. G. Jovin
Reduced Pretreatment Ipsilateral Middle Cerebral Artery Cerebral Blood Flow Is Predictive of Symptomatic Hemorrhage Post-Intra-Arterial Thrombolysis in Patients With Middle Cerebral Artery Occlusion
Stroke, October 1, 2006; 37(10): 2526 - 2530.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. R. Caplan
Stroke Thrombolysis: Slow Progress
Circulation, July 18, 2006; 114(3): 187 - 190.
[Full Text] [PDF]

Home page
 CirculationHome page
D. Georgiadis, S. Engelter, B. Tettenborn, H. Hungerbuhler, R. Luethy, F. Muller, M. Arnold, C. Giambarba, C. R. Baumann, H.-C. von Budingen, et al.
Early Recurrent Ischemic Stroke in Stroke Patients Undergoing Intravenous Thrombolysis
Circulation, July 18, 2006; 114(3): 237 - 241.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. I. Weintraub
Thrombolysis (Tissue Plasminogen Activator) in Stroke: A Medicolegal Quagmire
Stroke, July 1, 2006; 37(7): 1917 - 1922.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
H. S. Kim, D. H. Lee, C. W. Ryu, J. H. Lee, C. G. Choi, S. J. Kim, and D. C. Suh
Multiple Cerebral Microbleeds in Hyperacute Ischemic Stroke: Impact on Prevalence and Severity of Early Hemorrhagic Transformation After Thrombolytic Treatment.
Am. J. Roentgenol., May 1, 2006; 186(5): 1443 - 1449.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. Cocho, M. Borrell, J. Marti-Fabregas, J. Montaner, M. Castellanos, Y. Bravo, L. Molina-Porcel, R. Belvis, J.-A. Diaz-Manera, A. Martinez-Domeno, et al.
Pretreatment Hemostatic Markers of Symptomatic Intracerebral Hemorrhage in Patients Treated With Tissue Plasminogen Activator
Stroke, April 1, 2006; 37(4): 996 - 999.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
The IMS Study Investigators
Hemorrhage in the Interventional Management of Stroke Study
Stroke, March 1, 2006; 37(3): 847 - 851.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. Fisher, B. Ovbiagele, and J. L. Saver
The smoking-thrombolysis paradox and acute ischemic stroke
Neurology, February 14, 2006; 66(3): 458 - 458.
[Full Text] [PDF]

Home page
 StrokeHome page
J. H. Choi, B. T. Bateman, S. Mangla, R. S. Marshall, S. Prabhakaran, J. Chong, J. P. Mohr, H. Mast, and J. Pile-Spellman
Endovascular Recanalization Therapy in Acute Ischemic Stroke
Stroke, February 1, 2006; 37(2): 419 - 424.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. Trouillas and R. von Kummer
Classification and Pathogenesis of Cerebral Hemorrhages After Thrombolysis in Ischemic Stroke
Stroke, February 1, 2006; 37(2): 556 - 561.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H.-C. Koennecke
Cerebral microbleeds on MRI: Prevalence, associations, and potential clinical implications
Neurology, January 24, 2006; 66(2): 165 - 171.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
J. C. Hemphill III and P. Lyden
Stroke thrombolysis in the elderly: Risk or benefit?
Neurology, December 13, 2005; 65(11): 1690 - 1691.
[Full Text] [PDF]

Home page
 StrokeHome page
J. Berrouschot, J. Rother, J. Glahn, T. Kucinski, J. Fiehler, and G. Thomalla
Outcome and Severe Hemorrhagic Complications of Intravenous Thrombolysis With Tissue Plasminogen Activator in Very Old (>=80 Years) Stroke Patients
Stroke, November 1, 2005; 36(11): 2421 - 2425.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Kassner, T. Roberts, K. Taylor, F. Silver, and D. Mikulis
Prediction of Hemorrhage in Acute Ischemic Stroke Using Permeability MR Imaging
AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2213 - 2217.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
A. M. Demchuk, M. D. Hill, P. A. Barber, B. Silver, S. C. Patel, S. R. Levine, and for the NINDS rtPA Stroke Study Group, NIH
Importance of Early Ischemic Computed Tomography Changes Using ASPECTS in NINDS rtPA Stroke Study
Stroke, October 1, 2005; 36(10): 2110 - 2115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
L. H. Schwamm, E. S. Rosenthal, C. J. Swap, J. Rosand, G. Rordorf, F. S. Buonanno, M. G. Vangel, W. J. Koroshetz, and M. H. Lev
Hypoattenuation on CT Angiographic Source Images Predicts Risk of Intracerebral Hemorrhage and Outcome after Intra-Arterial Reperfusion Therapy
AJNR Am. J. Neuroradiol., August 1, 2005; 26(7): 1798 - 1803.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. Khatri, J. P. Broderick, A. M. Pancioli, E. C. Haley Jr, K. C. Johnston, P. D. Lyden, T. M. Hemmen, and For the TNK in Stroke Investigators
Risk of Thrombolysis-Associated Intracerebral Hemorrhage: The Need to Compare Apples With Apples * Response:
Stroke, June 1, 2005; 36(6): 1109 - 1110.
[Full Text] [PDF]

Home page
 JAMAHome page
L. B. Goldstein and D. L. Simel
Is This Patient Having a Stroke?
JAMA, May 18, 2005; 293(19): 2391 - 2402.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Benchenane, V. Berezowski, C. Ali, M. Fernandez-Monreal, J. P. Lopez-Atalaya, J. Brillault, J. Chuquet, A. Nouvelot, E. T. MacKenzie, G. Bu, et al.
Tissue-Type Plasminogen Activator Crosses the Intact Blood-Brain Barrier by Low-Density Lipoprotein Receptor-Related Protein-Mediated Transcytosis
Circulation, May 3, 2005; 111(17): 2241 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. Y. Kim, D. G. Na, S. S. Kim, K. H. Lee, J. W. Ryoo, and H. K. Kim
Prediction of Hemorrhagic Transformation in Acute Ischemic Stroke: Role of Diffusion-Weighted Imaging and Early Parenchymal Enhancement
AJNR Am. J. Neuroradiol., May 1, 2005; 26(5): 1050 - 1055.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
E. J. Versnick, H. M. Do, G. W. Albers, D. C. Tong, and M. P. Marks
Mechanical Thrombectomy for Acute Stroke
AJNR Am. J. Neuroradiol., April 1, 2005; 26(4): 875 - 879.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
W. M. Landau and A. Nassief
Editorial Comment-- Time to Burn the TOAST
Stroke, April 1, 2005; 36(4): 902 - 904.
[Full Text] [PDF]

Home page
 StrokeHome page
Abciximab Emergent Stroke Treatment Trial Investi
Emergency Administration of Abciximab for Treatment of Patients With Acute Ischemic Stroke: Results of a Randomized Phase 2 Trial
Stroke, April 1, 2005; 36(4): 880 - 890.
[Abstract] [Full Text] [PDF]

Home page
 Mayo Clin Proc.Home page
E. M. Manno, J. L. D. Atkinson, J. R. Fulgham, and E. F. M. Wijdicks
Emerging Medical and Surgical Management Strategies in the Evaluation and Treatment of Intracerebral Hemorrhage
Mayo Clin. Proc., March 1, 2005; 80(3): 420 - 433.
[Abstract] [PDF]

Home page
 StrokeHome page
M. Ribo, C. A. Molina, A. Rovira, M. Quintana, P. Delgado, J. Montaner, E. Grive, J. F. Arenillas, and J. Alvarez-Sabin
Safety and Efficacy of Intravenous Tissue Plasminogen Activator Stroke Treatment in the 3- to 6-Hour Window Using Multimodal Transcranial Doppler/MRI Selection Protocol
Stroke, March 1, 2005; 36(3): 602 - 606.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
E. C. Haley Jr, P. D. Lyden, K. C. Johnston, T. M. Hemmen, and the TNK in Stroke Investigators
A Pilot Dose-Escalation Safety Study of Tenecteplase in Acute Ischemic Stroke
Stroke, March 1, 2005; 36(3): 607 - 612.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. R. Sims, G. Rordorf, E. E. Smith, W. J. Koroshetz, M. H. Lev, F. Buonanno, and L. H. Schwamm
Arterial Occlusion Revealed by CT Angiography Predicts NIH Stroke Score and Acute Outcomes after IV tPA Treatment
AJNR Am. J. Neuroradiol., February 1, 2005; 26(2): 246 - 251.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Derex, M Hermier, P Adeleine, J-B Pialat, M Wiart, Y Berthezene, F Philippeau, J Honnorat, J-C Froment, P Trouillas, et al.
Clinical and imaging predictors of intracerebral haemorrhage in stroke patients treated with intravenous tissue plasminogen activator
J. Neurol. Neurosurg. Psychiatry, January 1, 2005; 76(1): 70 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Wintermark, N. J. Fischbein, W. S. Smith, N. U. Ko, M. Quist, and W. P. Dillon
Accuracy of Dynamic Perfusion CT with Deconvolution in Detecting Acute Hemispheric Stroke
AJNR Am. J. Neuroradiol., January 1, 2005; 26(1): 104 - 112.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
W. Hacke, G. Albers, Y. Al-Rawi, J. Bogousslavsky, A. Davalos, M. Eliasziw, M. Fischer, A. Furlan, M. Kaste, K. R. Lees, et al.
The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): A Phase II MRI-Based 9-Hour Window Acute Stroke Thrombolysis Trial With Intravenous Desmoteplase
Stroke, January 1, 2005; 36(1): 66 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Radiol.Home page
S F S Halpin
Brain imaging using multislice CT: a personal perspective
Br. J. Radiol., December 1, 2004; 77(suppl_1): S20 - S26.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. Zhang, Z. G. Zhang, C. Zhang, R. L. Zhang, and M. Chopp
Intravenous Administration of a GPIIb/IIIa Receptor Antagonist Extends the Therapeutic Window of Intra-Arterial Tenecteplase-Tissue Plasminogen Activator in a Rat Stroke Model
Stroke, December 1, 2004; 35(12): 2890 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. Y. Lee, D. I. Kim, S. H. Kim, S. I. Lee, H. W. Chung, Y. W. Shim, S. M. Kim, and J. H. Heo
Sequential Combination of Intravenous Recombinant Tissue Plasminogen Activator and Intra-Arterial Urokinase in Acute Ischemic Stroke
AJNR Am. J. Neuroradiol., October 1, 2004; 25(9): 1470 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
P. D. Mitsias, J. R. Ewing, M. Lu, M. M. Khalighi, M. Pasnoor, H. B. Ebadian, Q. Zhao, S. Santhakumar, M. A. Jacobs, N. Papamitsakis, et al.
Multiparametric Iterative Self-Organizing MR Imaging Data Analysis Technique for Assessment of Tissue Viability in Acute Cerebral Ischemia
AJNR Am. J. Neuroradiol., October 1, 2004; 25(9): 1499 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
V. Aiyagari, A. Gujjar, A. R. Zazulia, and M. N. Diringer
Hourly Blood Pressure Monitoring After Intravenous Tissue Plasminogen Activator for Ischemic Stroke: Does Everyone Need It?
Stroke, October 1, 2004; 35(10): 2326 - 2330.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
T. J. Ingall, W. M. O'Fallon, K. Asplund, L. R. Goldfrank, V. S. Hertzberg, T. A. Louis, and T. J. H. Christianson
Findings From the Reanalysis of the NINDS Tissue Plasminogen Activator for Acute Ischemic Stroke Treatment Trial
Stroke, October 1, 2004; 35(10): 2418 - 2424.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Ribo, J. Montaner, C. A. Molina, J. F. Arenillas, E. Santamarina, M. Quintana, and J. Alvarez-Sabin
Admission Fibrinolytic Profile Is Associated With Symptomatic Hemorrhagic Transformation in Stroke Patients Treated With Tissue Plasminogen Activator
Stroke, September 1, 2004; 35(9): 2123 - 2127.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Castellanos, R. Leira, J. Serena, M. Blanco, S. Pedraza, J. Castillo, and A. Davalos
Plasma Cellular-Fibronectin Concentration Predicts Hemorrhagic Transformation After Thrombolytic Therapy in Acute Ischemic Stroke
Stroke, July 1, 2004; 35(7): 1671 - 1676.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
P. Trouillas, L. Derex, F. Philippeau, N. Nighoghossian, J. Honnorat, M. Hanss, P. Ffrench, P. Adeleine, and M. Dechavanne
Early Fibrinogen Degradation Coagulopathy Is Predictive of Parenchymal Hematomas in Cerebral rt-PA Thrombolysis: A Study of 157 Cases
Stroke, June 1, 2004; 35(6): 1323 - 1328.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
T. Ben-Hur, J. E. Cohen, A. A. Rabinstein, L. H. Schwamm, and Bob. S. Carter
Case 5-2004: A Man with Slurred Speech and Left Hemiparesis
N. Engl. J. Med., May 20, 2004; 350(21): 2213 - 2214.
[Full Text] [PDF]

Home page
 StrokeHome page
The IMS Study Investigators
Combined Intravenous and Intra-Arterial Recanalization for Acute Ischemic Stroke: The Interventional Management of Stroke Study
Stroke, April 1, 2004; 35(4): 904 - 911.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
I. Linfante
Editorial Comment--Can MRI Reliably Detect Hyperacute Intracerebral Hemorrhage? Ask the Medical Student
Stroke, February 1, 2004; 35(2): 506 - 507.
[Full Text] [PDF]

Home page
 StrokeHome page
J. P. Broderick
William M. Feinberg Lecture: Stroke Therapy in the Year 2025: Burden, Breakthroughs, and Barriers to Progress
Stroke, January 1, 2004; 35(1): 205 - 211.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Montaner, I. Fernandez-Cadenas, C. A. Molina, J. Monasterio, J. F. Arenillas, M. Ribo, M. Quintana, P. Chacon, A. L. Andreu, and J. Alvarez-Sabin
Safety Profile of Tissue Plasminogen Activator Treatment Among Stroke Patients Carrying a Common Polymorphism (C-1562T) in the Promoter Region of the Matrix Metalloproteinase-9 Gene
Stroke, December 1, 2003; 34(12): 2851 - 2855.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
R. Handschu, R. Littmann, U. Reulbach, C. Gaul, J. G. Heckmann, B. Neundorfer, and M. Scibor
Telemedicine in Emergency Evaluation of Acute Stroke: Interrater Agreement in Remote Video Examination With a Novel Multimedia System
Stroke, December 1, 2003; 34(12): 2842 - 2846.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S. Gautier, O. Petrault, P. Gele, M. Laprais, M. Bastide, A. Bauters, D. Deplanque, B. Jude, J. Caron, and R. Bordet
Involvement of Thrombolysis in Recombinant Tissue Plasminogen Activator-Induced Cerebral Hemorrhages and Effect on Infarct Volume and Postischemic Endothelial Function
Stroke, December 1, 2003; 34(12): 2975 - 2979.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
J. M. Provenzale, R. Jahan, T. P. Naidich, and A. J. Fox
Assessment of the Patient with Hyperacute Stroke: Imaging and Therapy
Radiology, November 1, 2003; 229(2): 347 - 359.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
S.-W. Jeong, K. Chu, K.-H. Jung, S. U. Kim, M. Kim, and J.-K. Roh
Human Neural Stem Cell Transplantation Promotes Functional Recovery in Rats With Experimental Intracerebral Hemorrhage
Stroke, September 1, 2003; 34(9): 2258 - 2263.
[Abstract] [Full Text] [PDF]


Stroke Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1997 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.