This Article Full Text Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gorelick, P. B. Search for Related Content PubMed PubMed Citation Articles by Gorelick, P. B.

(Stroke. 1997;28:459-463.)
© 1997 American Heart Association, Inc.

Articles

Status of Risk Factors for Dementia Associated With Stroke

Philip B. Gorelick, MD, MPH

the Center for Stroke Research, Department of Neurologic Sciences, Rush Medical Center, Chicago, Ill.

Correspondence to Philip B. Gorelick, MD, MPH, Center for Stroke Research, Department of Neurologic Sciences, Rush Medical Center, 1645 W Jackson, Suite 400, Chicago, IL 60612.

Background Cognitive impairment associated with vascular disease may be the only preventable form of dementia of late life. Identification of risk factors for dementia associated with stroke may be a prelude to improved intervention.

Summary of Review I reviewed putative risk factors for dementia associated with stroke. These included demographic, atherogenic, stroke-related, and genetic factors. Key studies from the English literature were reviewed and graded according to quality of evidence ratings (classes I, II, and III). Although many of the cardiovascular disease risk factors are logical antecedents of dementia associated with stroke, age was the only factor that could be considered a well-documented risk factor.

Conclusions We should continue to support efforts directed at primary stroke prevention and the brain-at-risk and predementia stages. Additional rigorous epidemiological study is needed to clarify risk factors for dementia associated with stroke.

Key Words: dementia • risk factors • stroke prevention

This article has been cited by other articles:

				J. A. Luchsinger, B. Patel, M.-X. Tang, N. Schupf, and R. Mayeux Measures of Adiposity and Dementia Risk in Elderly Persons Arch Neurol, March 1, 2007; 64(3): 392 - 398. [Abstract] [Full Text] [PDF]

				Y. Fujiwara, P. H. M. Chaves, R. Takahashi, H. Amano, H. Yoshida, S. Kumagai, K. Fujita, D. G. Wang, and S. Shinkai Arterial Pulse Wave Velocity as a Marker of Poor Cognitive Function in an Elderly Community-Dwelling Population J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 607 - 612. [Abstract] [Full Text] [PDF]

				P. B. Gorelick William M. Feinberg Lecture: Cognitive Vitality and the Role of Stroke and Cardiovascular Disease Risk Factors Stroke, April 1, 2005; 36(4): 875 - 879. [Abstract] [Full Text] [PDF]

				P. B. Gorelick Risk Factors for Vascular Dementia and Alzheimer Disease Stroke, November 1, 2004; 35(11_suppl_1): 2620 - 2622. [Abstract] [Full Text] [PDF]

				W. K. Tang, S. S.M. Chan, H. F.K. Chiu, G. S. Ungvari, K. S. Wong, T. C.Y. Kwok, V. Mok, K.T. Wong, P. S. Richards, and A.T. Ahuja Frequency and Determinants of Poststroke Dementia in Chinese Stroke, April 1, 2004; 35(4): 930 - 935. [Abstract] [Full Text] [PDF]

				D. L. Nyenhuis, P. B. Gorelick, S. Freels, and D. C. Garron Cognitive and functional decline in African Americans with VaD, AD, and stroke without dementia Neurology, January 8, 2002; 58(1): 56 - 61. [Abstract] [Full Text] [PDF]

				J. A. Luchsinger, M.-X. Tang, Y. Stern, S. Shea, and R. Mayeux Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort Am. J. Epidemiol., October 1, 2001; 154(7): 635 - 641. [Abstract] [Full Text] [PDF]

				D. Laurin, R. Verreault, J. Lindsay, K. MacPherson, and K. Rockwood Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons Arch Neurol, March 1, 2001; 58(3): 498 - 504. [Abstract] [Full Text] [PDF]

				C. D. McCullagh, D. Craig, S. P. McIlroy, and A. P. Passmore Risk factors for dementia Advan. Psychiatr. Treat., January 1, 2001; 7(1): 24 - 31. [Full Text]

				R. Hebert, J. Lindsay, R. Verreault, K. Rockwood, G. Hill, and M.-F. Dubois Vascular Dementia : Incidence and Risk Factors in the Canadian Study of Health and Aging Stroke, July 1, 2000; 31(7): 1487 - 1493. [Abstract] [Full Text] [PDF]

				P. A. Wolf, G. P. Clagett, J. D. Easton, L. B. Goldstein, P. B. Gorelick, M. Kelly-Hayes, R. L. Sacco, and J. P. Whisnant Preventing Ischemic Stroke in Patients With Prior Stroke and Transient Ischemic Attack : A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association Stroke, September 1, 1999; 30(9): 1991 - 1994. [Full Text] [PDF]

				Z. Guo, L. Fratiglioni, L. Zhu, J. Fastbom, B. Winblad, and M. Viitanen Occurrence and Progression of Dementia in a Community Population Aged 75 Years and Older: Relationship of Antihypertensive Medication Use Arch Neurol, August 1, 1999; 56(8): 991 - 996. [Abstract] [Full Text] [PDF]

				L. T. Kwan, B. R. Reed, J. L. Eberling, N. Schuff, J. Tanabe, D. Norman, M. W. Weiner, and W. J. Jagust Effects of Subcortical Cerebral Infarction on Cortical Glucose Metabolism and Cognitive Function Arch Neurol, July 1, 1999; 56(7): 809 - 814. [Abstract] [Full Text] [PDF]

				P. B. Gorelick Cerebrovascular Disease in African Americans Stroke, December 1, 1998; 29(12): 2656 - 2664. [Full Text] [PDF]

				J. Chapman, N. Wang, T. A. Treves, A. D. Korczyn, and N. M. Bornstein ACE, MTHFR, Factor V Leiden, and APOE Polymorphisms in Patients With Vascular and Alzheimer's Dementia Stroke, July 1, 1998; 29(7): 1401 - 1404. [Abstract] [Full Text] [PDF]