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(Stroke. 1997;28:483-490.)
© 1997 American Heart Association, Inc.
Articles |
Absolute Quantitation of Diffusion Constants in Human Stroke
Presented in part at the Joint 3rd World Stroke Congress and 5th European Stroke Conference, Munich, Germany, September 1-4, 1996.
, PhD
From the Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Md.
Background and Purpose Animal studies have shown that MR diffusion imaging can outline acute ischemic regions before irreversible damage (infarction) occurs. To study evolution of ischemic lesions in humans, it is therefore important to quantify absolute diffusion constants (D values), but quantitation has not been reproducible among different clinics. These problems are explained, and a method for reproducible quantitation is suggested.
Methods Diffusion-weighted and absolute diffusion images
were acquired, and the absolute apparent diffusion constants in three
orthogonal spatial directions (Dxx,
Dyy, and Dzz) were
measured. These were combined to calculate images of the
orientation-independent apparent diffusion parameter
Dav=1/3
Trace{
}=1/3(Dxx+Dyy+Dzz).
Values of the individual diffusion constants and
Dav were evaluated in 6 patients and 6 normal
volunteers.
Results Patient data show that comparison of diffusion constants between contralateral and ipsilateral hemispheres after ischemia may give results varying by more than 100% depending on orientation. Findings in normal-appearing regions containing a mixture of gray and white matter in patients (n=5) and in normal volunteers (n=6) show that Dav=(0.92±0.11)x10–3 mm2/s, with a small intersubject variation, whereas Dxx, Dyy, and Dzz vary strongly. Hemispheric ratios (ipsilateral/contralateral [I/C]) in these subjects were (I/C)Dav=1.00±0.05, (I/C)Dxx=1.02±0.15, (I/C)Dyy=1.07±0.24, and (I/C)Dzz=0.96±0.28. The individual subjects in this group all had an (I/C)Dav within 10% of unity, while the other three ratios showed intersubject variations as large as 100%.
Conclusions (I/C)Dav ratios are a reliable means to quantitate changes in absolute diffusion constants for the study of stroke evolution independent of tissue orientation, gradient orientation, and diffusion time. The use of these ratios will enable reproducible intersubject and interclinic quantitation.
Key Words: diffusion • magnetic resonance imaging • stroke, acute • stroke assessment
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