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(Stroke. 1997;28:665-671.)
© 1997 American Heart Association, Inc.
Articles |
Reproducibility of In Vivo Carotid Intima-Media Thickness Measurements
A Review
From the Departments of Internal Medicine (S.D.J.M.K., J.-D.B), Clinical Epidemiology (A.A.), and Radiology (M.S. van L.), University Hospital Utrecht, The Netherlands.
Correspondence to Jan-Dirk Banga, MD, PhD, Department of Internal Medicine, University Hospital Utrecht, Heidelberglaan 100, PB 85500, 3508 GA Utrecht, Netherlands. E-mail a.algra{at}neuro.azu.nl.
Background The early phase of atherosclerosis can be studied by two-dimensional B-mode ultrasonography. Measurements of the combined thickness of the carotid intima and media are currently used as intermediate outcome in clinical trials. Comparison of results between studies is difficult because of the different methods of image acquisition and analysis used. We review these methods and the reported reproducibility of intima-media thickness (IMT) measurements.
Summary of Review Articles were collected using the MEDLINE literature search system and the references in the selected articles. Literature concerning human in vivo IMT measurements published in the English language in the period 1991 through 1995 was reviewed. A description of the methods of measuring IMT to determine intraobserver and/or interobserver variability was a prerequisite for inclusion. Twenty-three studies were included. Best reproducibility was found when measuring the mean IMT in the common carotid artery in more than one direction.
Conclusions We conclude that a consensus concerning the assessment of IMT is urgently needed. Variability of IMT measurements is lowest when determining the mean thickness in the common carotid artery in different directions.
Key Words: carotid arteries • observer variation • ultrasonics
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