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(Stroke. 1997;28:1458-1460.)
© 1997 American Heart Association, Inc.

Articles

Cerebral Blood Flow in Single and Multiple Lacunar Infarctions

Yoko Mochizuki, MD; Minoru Oishi, MD; Toshiaki Takasu, MD

From the Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.

Correspondence to Yoko Mochizuki, MD, Department of Neurology, Nihon University Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo 179, Japan. E-mail LEF00015{at}niftyserve.or.jp

Background and Purpose Single and multiple lacunar infarctions may have some difference in underlying diseases and cerebral blood flows. To determine the difference, we investigated underlying diseases and cerebral blood flows in single and multiple lacunar infarctions.

Methods Fifteen cases of lacunar infarction, 10 cases of multiple lacunar infarctions, and 16 control subjects were studied. Regional cerebral blood flow was measured within 14 days after stroke onset with the stable xenon CT method.

Results The rate of association of diabetes mellitus was higher in the multiple lacunar infarctions group than in the single lacunar infarction group. The blood flow in the cerebral cortex was significantly lower in the multiple lacunar infarctions group than in the single lacunar infarction group. The blood flow change by acetazolamide in the cerebral cortex was significantly lower in the multiple lacunar infarctions group than in the single lacunar infarction group.

Conclusions There is some difference in underlying diseases and cerebral blood flows between single and multiple lacunar infarctions.

Key Words: acetazolamide • cerebral blood flow • lacunar infarction • xenon

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