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(Stroke. 1997;28:1590-1594.)
© 1997 American Heart Association, Inc.
Articles |
Predictive Factors of Early Seizures After Acute Cerebrovascular Disease
From the Acute Stroke Unit, Service of Neurology (A.A., J.B.M., M.O., E.C.) and Intensive Care Unit (L.G.-E.), Hospitals de Barcelona de L'Aliança, Barcelona, Spain.
Correspondence to Dr Adrià Arboix, Servicio de Neurología, Hospitals de Barcelona de L'Aliança, Sant Antoni M. Claret 135, E-08025 Barcelona, Spain.
Background and Purpose Seizures within the first 48 hours of a first stroke or transient ischemic attack (TIA) are an independent prognostic factor for in-hospital mortality. The aim of this study was to determine predictive factors of early seizures in first-ever stroke patients.
Methods Data of 1220 first-ever stroke patients admitted
consecutively to an acute stroke unit of a 450-bed teaching hospital
between January 1986 and December 1993 were collected from a stroke
registry. Demographic, anamnestic, clinical, neurological, and
neuroimaging variables in the seizure and nonseizure group were
compared using the t test and the 
2
test. The independent predictive value of each variable on the
development of early seizures was assessed with a logistic regression
analysis.
Results Early epileptic seizures were diagnosed in 29 patients (2.4%). Seizures were significantly more frequent in patients with hemorrhagic stroke (4.3%) than in those with ischemic stroke (2%). Patients with seizures were significantly younger and significantly more likely to have acute confusional state, cortical involvement, large stroke, and involvement of the parietal, frontal, occipital, and temporal lobes than patients without seizures. The in-hospital mortality rate was 37.9% in the seizure group and 14.4% in the nonseizure group (P<.0005). After multivariate analysis, only cortical involvement (odds ratio of 6.01) and acute agitated confusional state (odds ratio of 4.44) were independent clinical factors for developing epileptic seizures.
Conclusions Cortical involvement in the neuroimaging studies and agitated acute confusional state at the onset of stroke were independent predictive factors of early seizures in first-ever stroke patients. The efficacy of anticonvulsant drugs in the prophylactic control of seizures should be assessed in prospective, randomized, double-blind clinical trials conducted in the subgroup of patients with the highest risk of developing epileptic seizures.
Key Words: epilepsy • stroke, acute • stroke outcome
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