From the NMR Research Center, Department of Neurology, Henry Ford Health
Sciences Center, Detroit, Mich, and the Department of Radiology (E.M.V.), The
University of Chicago (Illinois).
Correspondence to Yue Cao, PhD, NMR Research Center, Department of Neurology, NMR Laboratory, Henry Ford Hospital & Health Sciences Center, 2799 W Grand Blvd, Detroit, MI 48202-2689. E-mail yue{at}neurnis.neuro.hfh.edu
Background and Purpose—Studies of
cerebral activation of motor function after ischemic stroke may
enhance our understanding of the underlying mechanisms of motor
functional recovery, including the role of the noninfarcted
hemisphere.
Methods—Eight right-handed recovering hemiparetic or hemiplegic
patients were studied using functional MRI. Results were evaluated for
each patient to consider individual variability in original functional
organization, neuroanatomy, infarct size and extent, treatment,
age, and sex. The results were also pooled as a group for comparison
with a control group of eight right-handed normal subjects.
Results—In six of eight stroke patients, extended activation in
ipsilateral sensorimotor cortex was observed during paretic hand
movements. Bilateral activation of the primary sensorimotor cortex was
recorded in three of these six patients; ipsilateral activation
alone was recorded in the remaining three patients. Only two
patients had mild synkinesia. Furthermore, in two male patients, the
paretic hand movements activated extended areas of ipsilateral
premotor and dorsolateral prefrontal cortex, when compared with normal
subjects. In two patients with left frontal infarction, profound
activation in the right supramarginal gyrus and in the right premotor
cortex was observed during the ipsilateral paretic hand movements.
Conclusions—Synkinesia alone cannot explain the extent of
ipsilateral activation in primary sensorimotor cortex. The explanation
offered for our findings is that preexisting uncrossed motor neural
pathways may be accessed or recruited to compensate for damage to the
crossed motor pathways after ischemic stroke.
© 1998 American Heart Association, Inc.
Original Contributions
Pilot Study of Functional MRI to Assess Cerebral Activation of Motor Function After Poststroke Hemiparesis
Key Words: functional reorganization • magnetic resonance imaging • motor activity • stroke, ischemic
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|
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|
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|
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|
|
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|
|
|
|
|
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|
|
|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
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|
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