From Yagi Hospital (T.O., K.K., H.N., H.Y.); Second Department of
Internal Medicine, Faculty of Medicine, Kyushu University (S.I., M.F.),
Fukuoka, Japan.
Correspondence to Tsuyoshi Omae, MD, Cerebrovascular Disease Clinic, National Kyushu Medical Center, Jigyo-hama 1–8-1, Chuo-ku, Fukuoka, Japan, 810. E-mail omae{at}qmed.hosp.go.jp
Background and Purpose—There are
several reports that have studied the effects of hyperbaric oxygen
(HBO) on cerebral blood flow (CBF). However, most of the reports have
been of animal experiments, and human studies are few so far. The aim
of this study is to clarify the relationship between HBO and CBF
in humans.
Methods—Middle cerebral arterial blood flow velocity
(MCV) was measured using transcranial Doppler (TCD)
technique in a multiplace hyperbaric chamber. The Doppler probe was
fixed on the temporal region by a head belt, and the transcutaneous gas
measurement apparatus (tcPO2 and
tcPCO2) was fixed on the chest wall. MCV and
transcutaneous gas were measured continuously in eight healthy
volunteers under four various conditions: 1 atmosphere absolute (ATA)
air, 1 ATA oxygen (O2), 2 ATA air, and 2 ATA
O2. On the next step, the effect of environmental pressure
was studied in another eight healthy volunteers, in whom the
tcPo2 was kept at almost the same level under conditions of
both 1 ATA and 4 ATA by inhaling oxygen at 1 ATA.
Results—MCV of 1 ATA O2, 2 ATA air, and 2 ATA
O2 decreased, and tcPO2 increased
significantly in comparison with that of 1 ATA air. A significant
difference in MCV was observed between the O2 group and the
air group under the same pressure circumstance. On the other hand,
there were no differences in MCV or tcPO2
between 4 ATA air and 1 ATA plus O2, and the influence for
the MCV of the environmental pressure was not observed.
Conclusions—We conclude that hyperoxemia caused by HBO reduces
the CBF, but the high atmospheric pressure per se does not influence
the CBF in humans.
© 1998 American Heart Association, Inc.
Original Contributions
Effects of High Atmospheric Pressure and Oxygen on Middle Cerebral Blood Flow Velocity in Humans Measured by Transcranial Doppler
Key Words: cerebral blood flow • hyperbaric oxygenation • oxygen • ultrasonics
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