From Unità di Aterosclerosi e Trombosi (M.M., E.G., G.V., G.C.)
and Patologia Molecolare (D.S., C.G., G.M., S.P.), I.R.C.C.S. "Casa
Sollievo della Sofferenza," S. Giovanni Rotondo; Istituto di Medicina
Interna e Geriatria, Università di Palermo (A.P., G.D.M.); and
Patologia Molecolare, Università Cattolica S.C., Rome, Italy (V.M.F.).
Correspondence and reprint requests to Maurizio Margaglione, MD, Unità di Aterosclerosi e Trombosi, I.R.C.C.S. "Casa Sollievo della Sofferenza," viale Cappuccini, San Giovanni Rotondo (FG) 71013, Italy.
Background and Purpose—The
Methods—The apoE
Results—The frequency of the apoE
Conclusions—Our data show an association between apoE gene and a
personal history of ischemic stroke and support the possibility
that the apoE gene is a susceptibility locus for the risk of
cerebrovascular ischemic disease.
© 1998 American Heart Association, Inc.
Original Contributions
Prevalence of Apolipoprotein E Alleles in Healthy Subjects and Survivors of Ischemic Stroke
An Italian Case-Control Study
4
allele of the apolipoprotein E (apoE) has been related to the
occurrence of myocardial infarction, but its association with
ischemic stroke is controversial. We have evaluated the
relation between apoE alleles and the occurrence of
cerebrovascular ischemia. genotypes of 100 patients with a
documented history of ischemic stroke without clinically
apparent dementia (stroke+) and 108 subjects without such history
(stroke-) were determined. The relative frequency of the apoE
alleles and genotypes was estimated in 398 healthy subjects
aged <40 years from the same ethnic background. 4 allele in stroke+
(0.18 [95% CI, 0.12 to 0.25]) was higher than in stroke- (0.07
[95% CI, 0.03 to 0.12]; P<.001) or in healthy
subjects (0.09 [95% CI, 0.07 to 0.12]; P<.001).
Carriers of the 4 allele differed between stroke+ (0.30 [95%
CI, 0.19 to 0.42]) and stroke- (0.12 [95% CI, 0.5 to 0.22];
P=.004) or healthy subjects (0.16 [95% CI; 0.12 to
0.22]; P=.015). Accordingly, 3/3 homozygotes were
less frequent in stroke+ (0.59 [95% CI, 0.45 to 0.71]) than in
stroke- (0.72 [95% CI, 0.59 to 0.82]; P=.063) or in
healthy subjects (0.73 [95% CI, 0.67 to 0.78];
P=.01). In a multiple logistic regression
analysis, age (P<.03), positive family history
(P<.04) and apoE (P<.002) independently
contributed to a stroke history, with 4 carriers exhibiting a higher
estimated risk (odds ratio, 5.05).
Key Words: apolipoprotein E • risk factors • stroke • thrombosis
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