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From the Departments of Psychiatry (B.S.G., E.K.-G., C.A.) and Radiology
(M.A., M.P.), Long Island Jewish Medical Center, Glen Oaks, NY, and Albert
Einstein College of Medicine, Bronx, NY, and the Department of Psychiatry
(K.R.R.K.), Duke University Medical Center, Durham, NC.
Correspondence to Blaine S. Greenwald, MD, Hillside Hospital–Research Building, Long Island Jewish Medical Center, 75–59 263rd St, Glen Oaks, NY 11004. E-mail greenwal{at}lij.edu
Background and Purpose—Increased
frequency and severity of signal hyperintensities have been regularly
reported in elderly depressed patients compared with normal subjects,
however, greater neuroanatomic localization of lesions has been
limited.
Methods—T2-weighted MRI scans in elderly depressed patients
(n=35) and normal comparison subjects (n=31) were assessed for signal
hyperintensities in lateralized discrete brain regions.
Results—Logistic regression revealed that left frontal deep white
matter (P<.005) and left putaminal
(P<.04) hyperintensities significantly predicted
depressive group assignment.
Conclusions—Findings suggest that greater neuroanatomic
localization of hyperintensities than heretofore appreciated may relate
to late-life depression.
© 1998 American Heart Association, Inc.
Original Contributions
Neuroanatomic Localization of Magnetic Resonance Imaging Signal Hyperintensities in Geriatric Depression
Key Words: depression • elderly • leukoaraiosis • magnetic resonance imaging
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