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(Stroke. 1998;29:1398-1400.)
© 1998 American Heart Association, Inc.

Original Contributions

Frequency of the 20210 GA Mutation in the 3'-Untranslated Region of the Prothrombin Gene in 35 Cases of Cerebral Venous Thrombosis

V. Biousse, MD; J. Conard, PhD; C. Brouzes, MD; M. H. Horellou, MD; A. Ameri, MD; M. G. Bousser, MD

From the Service de Neurologie, Hôpital Lariboisière (V.B., M.G.B.), and the Service d'Hématologie Biologique, Hôtel Dieu (J.C., C.B., M.H.H.), Paris, and the Service de Neurologie, Hôpital de Meaux (A.A.), Meaux, France.

Background and Purpose—A novel sequence variation in the 3'-untranslated region of the prothrombin (factor II) gene (nucleotide 20210 GA) has been recently described as a risk factor for deep vein thrombosis and pulmonary embolism. It is found in 1% to 4% of healthy subjects. We studied the frequency of this factor II variant in patients with cerebral venous thrombosis.

Methods—The 20210A allele of the prothrombin gene was studied after DNA extraction, polymerase chain reaction amplification, and HindIII digestion in 35 patients with magnetic resonance imaging or angiographically confirmed cerebral venous thrombosis (23 women and 12 men, aged 11 to 71 years).

Results—Two patients (5.7%) had the 20210A allele of the prothrombin gene. Both had other risk factors for thrombosis (use of oral contraceptives and of intrathecal steroids).

Conclusions—The 20210A allele of the prothrombin gene in association with other prothrombic factors may increase the risk of cerebral venous thrombosis, but case-control studies will be necessary to clarify these associations.

Key Words: cerebral veins • venous thrombosis • thrombophilia

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