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(Stroke. 1972;3:27.)
© 1972 American Heart Association, Inc.

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Papaverine Hydrochloride and Experimental Hemorrhagic Cerebral Arterial Spasm

Akio Kuwayama M.D.¹; Nicholas T. Zervas M.D.²; Akira Shintani M.D.³; Kenneth S. Pickren B.SC.⁴

¹ Research Fellow, Department of Neurosurgery, Harvard Medical School and Beth Israel Hospital, 330 Brookline Avenue, Boston, Massachusetts, 02115
² Associate Professor, Department of Neurosurgery, Harvard Medical School and Beth Israel Hospital, 330 Brookline Avenue, Boston, Massachusetts, 02115
³ Clinical Fellow, Department of Neurosurgery, Harvard Medical School and Beth Israel Hospital, 330 Brookline Avenue, Boston, Massachusetts, 02115
⁴ Research Assistant, Department of Neurosurgery, Harvard Medical School and Beth Israel Hospital, 330 Brookline Avenue, Boston, Massachusetts, 02115

Chronic hemorrhagic spasm of the basilar artery was produced in beagle dogs by introducing blood into the cisterna magna. Spasm was evaluated by means of vertebral angiography. Papaverine hydrochloride was administered intravenously, intracisternally as well as intra-arterially. The intracisternal route was the more effective in combating spasm but the effect was transitory. The results suggest that the treatment of spasm by chemical means in subarachnoid hemorrhage using agents currently available would require continuous topical application.

Key Words: aneurysm • subarachnoid hemorrhage • basilar artery • angiography

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