This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by SIMEONE, F. A. Articles by TREPPER, P. Search for Related Content PubMed PubMed Citation Articles by SIMEONE, F. A. Articles by TREPPER, P.

(Stroke. 1972;3:449.)
© 1972 American Heart Association, Inc.

---

Cerebral Vasospasm With Infarction

FREDERICK A. SIMEONE M.D.¹ PETER TREPPER A.B.²

¹ University of Pennylvania School of Medicine
² Department of Neurosurgery, Pennsylvania Hospital and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Department of Neurosurgery, Pennsylvania Hospital, 800 Spruce Street, Philadelphia, Pennsylvania, 19107

A case of intense unilateral cerebral vasospasm with appropriate neurological deficit following rupture of a posterior communicating aneurysm was followed with serial angiography. Associated with the initially intense spasm was subsequent regional hyperperfusion with early venous filling which disappeared as signs of focal cerebral atrophy ensued. These angiographical findings can explain previous reported autopsy demonstrations of focal infarction in the distribution of aneurysm-bearing cerebral vessels. Laboratory cerebral blood flow studies in conjunction with experimental subarachnoid hemorrhage indicate that constriction of major cerebral arteries to less than one-half of their normal caliber is associated with reduction in regional cerebral blood flow to infarction levels.

Key Words: cerebral aneurysm • luxury perfusion • cerebral blood flow • subarachnoid hemorrhage

This article has been cited by other articles:

				J.-i. Hamada, Y. Kai, M. Morioka, S. Yano, T. Mizuno, T. Hirano, K. Kazekawa, and Y. Ushio Effect on Cerebral Vasospasm of Coil Embolization Followed by Microcatheter Intrathecal Urokinase Infusion Into the Cisterna Magna: A Prospective Randomized Study Stroke, November 1, 2003; 34(11): 2549 - 2554. [Abstract] [Full Text] [PDF]

				K. Toyoda, F. M. Faraci, Y. Watanabe, T. Ueda, J. J. Andresen, Y. Chu, S. Otake, and D. D. Heistad Gene Transfer of Calcitonin Gene-Related Peptide Prevents Vasoconstriction After Subarachnoid Hemorrhage Circ. Res., October 27, 2000; 87(9): 818 - 824. [Abstract] [Full Text] [PDF]