(Stroke. 1999;30:2013-2018.)
© 1999 American Heart Association, Inc.
Original Contributions |
Chlamydia pneumoniae Antibodies and High Lipoprotein(a) Levels Do Not Predict Ischemic Cerebral Infarctions
Results From a Nested Case-Control Study in Northern Sweden
From the Departments of Clinical Chemistry (C.A.G., G.H.D.), Medicine (B.S.), Virology (J.B.), and Public Health and Clinical Medicine (H.S., L.W., G.H.), Umeå University, Sweden.
Correspondence to Christine Ahlbeck Glader, MD, Department of Clinical Chemistry, Umeå University, SE-901 85 Umeå, Sweden. E-mail christine.ahlbeck.glader{at}klinkemi.umu.se
Background and Purpose—An association between high lipoprotein(a) [Lp(a)] levels and positive Chlamydia pneumoniae IgG titers in coronary artery disease has been described. The possibility of predicting ischemic stroke by measurements of plasma Lp(a) and C pneumoniae antibodies was investigated.
Methods—This incident case-control study included 101 case subjects (cases) who had suffered ischemic cerebral infarctions and 201 matched control subjects (controls). The study population was nested within the Västerbotten Intervention Program or the WHO MONICA project. Plasma samples were measured for C pneumoniae–specific IgG and IgA antibodies and Lp(a).
Results—A significantly higher mean Lp(a) level was found in female cases than in female controls. However, plasma Lp(a) was unable to predict ischemic cerebral infarctions in either women or men. The proportion of individuals with positive C pneumoniae–specific IgG or IgA titers did not differ between cases and controls. Antibody titers were unable to predict a future stroke. The proportion of individuals with a positive C pneumoniae IgG titer in combination with a high Lp(a) level did not differ significantly between cases and controls.
Conclusions—These data suggest that there is no association between baseline plasma Lp(a) levels, presence of C pneumoniae antibodies, and future ischemic cerebral infarctions. Furthermore, no evidence of an interactive effect between high Lp(a) levels and C pneumoniae IgG titers was found. However, selection bias and a recent C pneumoniae epidemic may have influenced the results.
Key Words: lipoprotein(a) • ischemic cerebrovascular disease • Chlamydia pneumoniae
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
Bibliography Scand J Public Health, November 1, 2003; 31(61_suppl): 85 - 91. [PDF]
|
|
|
|
|
|
P. J. Lindsberg and A. J. Grau Inflammation and Infections as Risk Factors for Ischemic Stroke Stroke, October 1, 2003; 34(10): 2518 - 2532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sun, Z. Li, H. Zhang, A. Ma, Y. Liao, D. Wang, B. Zhao, Z. Zhu, J. Zhao, Z. Zhang, et al. Pentanucleotide TTTTA Repeat Polymorphism of Apolipoprotein(a) Gene and Plasma Lipoprotein(a) Are Associated With Ischemic and Hemorrhagic Stroke in Chinese: A Multicenter Case-Control Study in China Stroke, July 1, 2003; 34(7): 1617 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Cagli, N Oktar, T Dalbasti, S Erensoy, N Ozdamar, S Goksel, A Sayiner, and A Bilgic Failure to detect Chlamydia pneumoniae DNA in cerebral aneursymal sac tissue with two different polymerase chain reaction methods J. Neurol. Neurosurg. Psychiatry, June 1, 2003; 74(6): 756 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vainas, H. A.J.M. Kurvers, W. H. Mess, R. d. Graaf, R. Ezzahiri, J. H.M. Tordoir, G.-W. H. Schurink, C. A. Bruggeman, and P. J.E.H.M. Kitslaar Chlamydia pneumoniae Serology Is Associated With Thrombosis-Related but Not With Plaque-Related Microembolization During Carotid Endarterectomy Stroke, May 1, 2002; 33(5): 1249 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Gorelick Stroke Prevention Therapy Beyond Antithrombotics: Unifying Mechanisms in Ischemic Stroke Pathogenesis and Implications for Therapy: An Invited Review Stroke, March 1, 2002; 33(3): 862 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Elkind, J. Cheng, B. Boden-Albala, T. Rundek, J. Thomas, H. Chen, L. E. Rabbani, R. L. Sacco, and A. G. Thrift Tumor Necrosis Factor Receptor Levels Are Associated With Carotid Atherosclerosis * Editorial Comment Stroke, January 1, 2002; 33(1): 31 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. U. Heuschmann, D. Neureiter, M. Gesslein, B. Craiovan, M. Maass, G. Faller, G. Beck, B. Neundoerfer, and P. L. Kolominsky-Rabas Association Between Infection With Helicobacter pylori and Chlamydia pneumoniae and Risk of Ischemic Stroke Subtypes: Results From a Population-Based Case-Control Study Stroke, October 1, 2001; 32(10): 2253 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Virok, Z. Kis, L. Karai, L. Intzedy, K. Burian, A. Szabo, B. Ivanyi, E. Gonczol, and M. S. Elkind Chlamydia pneumoniae in Atherosclerotic Middle Cerebral Artery Editorial Comment Stroke, September 1, 2001; 32(9): 1973 - 1976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hoffmeister, D. Rothenbacher, G. Bode, K. Persson, W. Marz, M. A. Nauck, H. Brenner, V. Hombach, and W. Koenig Current Infection With Helicobacter pylori, but Not Seropositivity to Chlamydia pneumoniae or Cytomegalovirus, Is Associated With an Atherogenic, Modified Lipid Profile Arterioscler. Thromb. Vasc. Biol., March 1, 2001; 21(3): 427 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J Milionis, A. F Winder, and D. P Mikhailidis Lipoprotein (a) and stroke J. Clin. Pathol., July 1, 2000; 53(7): 487 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. V. Elkind, I-F. Lin, J. T. Grayston, and R. L. Sacco Chlamydia pneumoniae and the Risk of First Ischemic Stroke : The Northern Manhattan Stroke Study Stroke, July 1, 2000; 31(7): 1521 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Wityk and S. Kittner Lipoprotein(a) and the Risk of Stroke Stroke, May 1, 2000; 31 (5): 1194 - 1198. [Full Text]
|
|