(Stroke. 1999;30:550-555.)
© 1999 American Heart Association, Inc.
Original Contributions |
Cross-Sectional and 4-Year Longitudinal Associations Between Brachial Pulse Pressure and Common Carotid Intima-Media Thickness in a General Population
The EVA Study
From the National Institute of Health and Medical Research (INSERM), Unit 258 (M.Z., C.B.-K., D.C., P.D.), INSERM Unit 360 (C.B.), and Centre de Diagnostic et de Prévention Neurovasculaire (P.J.T), Paris, and Centre d'examen EVA-INSERM (C.L.), Nantes, France.
Correspondence to Mahmoud Zureik, MD, PhD, INSERM U258, 16 Av. Paul Vaillant Couturier, 94807 Villejuif Cedex, France.
Background and Purpose—The cross-sectional and 4-year longitudinal associations between brachial pulse pressure (PP) and ultrasound measurements of common carotid intima-media thickness (CCA-IMT) were assessed.
Methods—A population of 957 volunteers aged 59 to 71 years was recruited from the electoral rolls of the city of Nantes (western France) and reexamined 4 years later. Longitudinal changes in PP and CCA-IMT were computed as the difference between 4-year follow-up and baseline values.
Results—Baseline CCA-IMT and PP were positively associated in both age- and sex-adjusted analysis (partial correlation coefficient=0.20, P<0.001) and in multivariate analysis adjusted for traditional cardiovascular risk factors and mean blood pressure (partial correlation coefficient=0.18, P<0.001). In longitudinal analysis, baseline PP was associated with the change in 4-year CCA-IMT (partial correlation coefficient=0.11, P<0.001), and baseline CCA-IMT was a predictor of the 4-year change in PP (partial correlation coefficient=0.10, 0.001<P<0.01). No association between mean blood pressure and CCA-IMT was observed once PP was taken into account, in either cross-sectional or longitudinal analyses (partial correlation coefficients ranged from 0.00 to 0.03). Similar patterns of results were observed in hypertensive, nonhypertensive, and antihypertensive-treated and -nontreated subjects.
Conclusions—This longitudinal study of a large population of relatively aged subjects suggests that elevated levels of PP are associated with the progression of CCA-IMT, and increased CCA-IMT is associated with PP widening. The nature of these relationships and whether atherosclerosis progression over time is involved or not in these associations merit further investigations.
Key Words: aged • blood pressure • carotid arteries • ultrasonography
This article has been cited by other articles:
 |
|
 |
|
  O. T. Raitakari, M. Juonala, L. Taittonen, A. Jula, T. Laitinen, M. Kahonen, and J. S.A. Viikari Pulse Pressure in Youth and Carotid Intima-Media Thickness in Adulthood: The Cardiovascular Risk in Young Finns Study Stroke, April 1, 2009; 40(4): 1519 - 1521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Prati, A. Tosetto, D. Vanuzzo, G. Bader, M. Casaroli, L. Canciani, S. Castellani, and P.-J. Touboul Carotid Intima Media Thickness and Plaques Can Predict the Occurrence of Ischemic Cerebrovascular Events Stroke, September 1, 2008; 39(9): 2470 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wintermark, S.S. Jawadi, J.H. Rapp, T. Tihan, E. Tong, D.V. Glidden, S. Abedin, S. Schaeffer, G. Acevedo-Bolton, B. Boudignon, et al. High-Resolution CT Imaging of Carotid Artery Atherosclerotic Plaques AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 875 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Qiu, C. Depre, K. Ghosh, R. G. Resuello, F. F. Natividad, F. Rossi, A. Peppas, Y.-T. Shen, D. E. Vatner, and S. F. Vatner Mechanism of Gender-Specific Differences in Aortic Stiffness With Aging in Nonhuman Primates Circulation, August 7, 2007; 116(6): 669 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Dumont, M. Zureik, D. Cottel, M. Montaye, P. Ducimetiere, P. Amouyel, and T. Brousseau Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness J. Med. Genet., August 1, 2007; 44(8): 526 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, P. Factor-Litvak, G. R. Howe, J. H. Graziano, P. Brandt-Rauf, F. Parvez, A. van Geen, and H. Ahsan Arsenic Exposure from Drinking Water, Dietary Intakes of B Vitamins and Folate, and Risk of High Blood Pressure in Bangladesh: A Population-based, Cross-sectional Study Am. J. Epidemiol., March 1, 2007; 165(5): 541 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Bots, D. Baldassarre, A. Simon, E. de Groot, D. H. O'Leary, W. Riley, J. J. Kastelein, and D. E. Grobbee Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations? Eur. Heart J., February 2, 2007; 28(4): 398 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Crouse III Thematic review series: Patient-Oriented Research. Imaging atherosclerosis: state of the art J. Lipid Res., August 1, 2006; 47(8): 1677 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-J. Touboul, J. Labreuche, E. Vicaut, P. Amarenco, and on behalf of the GENIC Investigators Carotid Intima-Media Thickness, Plaques, and Framingham Risk Score as Independent Determinants of Stroke Risk Stroke, August 1, 2005; 36(8): 1741 - 1745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Desvarieux, R. T. Demmer, T. Rundek, B. Boden-Albala, D. R. Jacobs Jr, R. L. Sacco, and P. N. Papapanou Periodontal Microbiota and Carotid Intima-Media Thickness: The Oral Infections and Vascular Disease Epidemiology Study (INVEST) Circulation, February 8, 2005; 111(5): 576 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. V. Nair, D. Waters, W. Rogers, G. J. Kowalchuk, T. D. Stuckey, and D. M. Herrington Pulse Pressure and Coronary Atherosclerosis Progression in Postmenopausal Women Hypertension, January 1, 2005; 45(1): 53 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Amarenco, J. Labreuche, P. Lavallee, and P.-J. Touboul Statins in Stroke Prevention and Carotid Atherosclerosis: Systematic Review and Up-to-Date Meta-Analysis Stroke, December 1, 2004; 35(12): 2902 - 2909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Mackinnon, P. Jerrard-Dunne, M. Sitzer, A. Buehler, S. von Kegler, and H. S. Markus Rates and Determinants of Site-Specific Progression of Carotid Artery Intima-Media Thickness: The Carotid Atherosclerosis Progression Study Stroke, September 1, 2004; 35(9): 2150 - 2154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zureik, P. Galan, S. Bertrais, L. Mennen, S. Czernichow, J. Blacher, P. Ducimetiere, and S. Hercberg Effects of Long-Term Daily Low-Dose Supplementation With Antioxidant Vitamins and Minerals on Structure and Function of Large Arteries Arterioscler. Thromb. Vasc. Biol., August 1, 2004; 24(8): 1485 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Herrington, W. V. Brown, L. Mosca, W. Davis, B. Eggleston, W. G. Hundley, and J. Raines Relationship Between Arterial Stiffness and Subclinical Aortic Atherosclerosis Circulation, July 27, 2004; 110(4): 432 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, S. Kony, C. Neukirch, D. Courbon, B. Leynaert, D. Vervloet, P. Ducimetiere, and F. Neukirch Bronchial Hyperresponsiveness to Methacholine Is Associated With Increased Common Carotid Intima-Media Thickness in Men Arterioscler. Thromb. Vasc. Biol., June 1, 2004; 24(6): 1098 - 1103. [Abstract] [Full Text]
|
|
|
|
|
|
C. Qiu, B. Winblad, M. Viitanen, and L. Fratiglioni Pulse Pressure and Risk of Alzheimer Disease in Persons Aged 75 Years and Older: A Community-Based, Longitudinal Study Stroke, March 1, 2003; 34(3): 594 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Lakatta and D. Levy Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A "Set Up" for Vascular Disease Circulation, January 7, 2003; 107(1): 139 - 146. [Full Text] [PDF]
|
|
|
|
|
|
J. R. Crouse III, R. Tang, M. A. Espeland, J. G. Terry, T. Morgan, and M. Mercuri Associations of Extracranial Carotid Atherosclerosis Progression With Coronary Status and Risk Factors in Patients With and Without Coronary Artery Disease Circulation, October 15, 2002; 106(16): 2061 - 2066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Pini, M. C. Cavallini, F. Bencini, G. Silvestrini, E. Tonon, W. De Alfieri, N. Marchionni, M. Di Bari, R. B. Devereux, G. Masotti, et al. Cardiovascular remodeling is greater in isolated systolic hypertension than in diastolic hypertension in older adults: the Insufficienza Cardiaca negli Anziani Residenti (ICARE) a Dicomano Study J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1283 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Viazzi, G. Leoncini, D. Parodi, M. Ravera, E. Ratto, S. Vettoretti, C. Tomolillo, M. D. Sette, G. P. Bezante, G. Deferrari, et al. Pulse pressure and subclinical cardiovascular damage in primary hypertension Nephrol. Dial. Transplant., October 1, 2002; 17(10): 1779 - 1785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, L. Robert, D. Courbon, P.-J. Touboul, L. Bizbiz, and P. Ducimetiere Serum Elastase Activity, Serum Elastase Inhibitors, and Occurrence of Carotid Atherosclerotic Plaques: The Etude sur le Vieillissement Arteriel (EVA) Study Circulation, June 4, 2002; 105(22): 2638 - 2645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Meraviglia, E. Maggi, G. Bellomo, M. Cursi, G. Fanelli, and F. Minicucci Autoantibodies Against Oxidatively Modified Lipoproteins and Progression of Carotid Restenosis After Carotid Endarterectomy Stroke, April 1, 2002; 33(4): 1139 - 1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Chambless, A. R. Folsom, V. Davis, R. Sharrett, G. Heiss, P. Sorlie, M. Szklo, G. Howard, and G. W. Evans Risk Factors for Progression of Common Carotid Atherosclerosis: The Atherosclerosis Risk in Communities Study, 1987-1998 Am. J. Epidemiol., January 1, 2002; 155(1): 38 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zureik, F. Kauffmann, P.-J. Touboul, D. Courbon, and P. Ducimetiere Association Between Peak Expiratory Flow and the Development of Carotid Atherosclerotic Plaques Arch Intern Med, July 9, 2001; 161(13): 1669 - 1676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. F. Terpstra, J. F. May, A. J. Smit, P. A. de Graeff, F. H. Schuurman, B. M.-d. Jong, and H. J. G. M. Crijns Silent ST Depression and Cardiovascular End-Organ Damage in Newly Found, Older Hypertensives Hypertension, April 1, 2001; 37(4): 1083 - 1088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paterniti, M. Zureik, P. Ducimetiere, P.-J. Touboul, J.-M. Feve, and A. Alperovitch Sustained Anxiety and 4-Year Progression of Carotid Atherosclerosis Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 136 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-L. Liang, L. M. Shiel, H. Teede, D. Kotsopoulos, J. McNeil, J. D. Cameron, and B. P. McGrath Effects of Blood Pressure, Smoking, and Their Interaction on Carotid Artery Structure and Function Hypertension, January 1, 2001; 37(1): 6 - 11. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-J. Touboul, A. Elbaz, C. Koller, C. Lucas, V. Adrai, F. Chedru, P. Amarenco, and f. t. G. Investigators Common Carotid Artery Intima-Media Thickness and Brain Infarction : The Etude du Profil Genetique de l'Infarctus Cerebral (GENIC) Case-Control Study Circulation, July 18, 2000; 102(3): 313 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zureik, P. Ducimetiere, P.-J. Touboul, D. Courbon, C. Bonithon-Kopp, C. Berr, and C. Magne Common Carotid Intima-Media Thickness Predicts Occurrence of Carotid Atherosclerotic Plaques : Longitudinal Results From the Aging Vascular Study (EVA) Study Arterioscler. Thromb. Vasc. Biol., June 1, 2000; 20(6): 1622 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Safar, J. Blacher, J. J. Mourad, and G. M. London Stiffness of Carotid Artery Wall Material and Blood Pressure in Humans : Application to Antihypertensive Therapy and Stroke Prevention Stroke, March 1, 2000; 31(3): 782 - 790. [Abstract] [Full Text] [PDF]
|
|