(Stroke. 1999;30:736-743.)
© 1999 American Heart Association, Inc.
Original Contributions |
Stroke Incidence and Survival Among Middle-Aged Adults
9-Year Follow-Up of the Atherosclerosis Risk in Communities (ARIC) Cohort
From the Department of Epidemiology (W.D.R.) and Collaborative Studies Coordinating Center, Department of Biostatistics (L.E.C., C.H.W.), University of North Carolina, Chapel Hill, NC; Division of Epidemiology, University of Minnesota, Minneapolis, MN (A.R.F., P.G.M., E.S.); Department of Public Health Science, Wake Forest University School of Medicine, Winston-Salem, NC (G.H.); and the National Heart, Lung, and Blood Institute, Bethesda, Md (L.S.C.).
Correspondence to Wayne D. Rosamond, PhD, Department of Epidemiology, University of North Carolina, 137 East Franklin St, Suite 306, Chapel Hill, NC 27514. E-mail wayne_rosamond{at}unc.edu
Background and Purpose—Although stroke mortality rates in the United States are well documented, assessment of incidence rates and case fatality are less well studied.
Methods—A cohort of 15 792 men and women aged 45 to 64 years from a population sample of households in 4 US communities was followed from 1987 to 1995, an average of 7.2 years. Incident strokes were identified through annual phone contacts and hospital record searching and were then validated.
Results—Of the 267 incident definite or probable strokes, 83% (n=221) were categorized as ischemic strokes, 10% (n=27) were intracerebral hemorrhages, and 7% (n=19) were subarachnoid hemorrhages. The age-adjusted incidence rate (per 1000 person-years) of total strokes was highest among black men (4.44), followed by black women (3.10), white men (1.78), and white women (1.24). The black versus white age-adjusted rate ratio (RR) for ischemic stroke was 2.41 (95% CI, 1.85 to 3.15), which was attenuated to 1.38 (95% CI, 1.01 to 1.89) after adjustment for baseline hypertension, diabetes, education level, smoking status, and prevalent coronary heart disease. There was a tendency for the adjusted case fatality rates to be higher among blacks and men, although none of the case fatality comparisons across sex or race was statistically significant.
Conclusions—After accounting for established baseline risk factors, blacks still had a 38% greater risk of incident ischemic stroke compared with whites. Identification of new individual and community-level risk factors accounting for the elevated incidence of stroke requires further investigation and incorporation into intervention planning.
Key Words: cerebral infarction • epidemiology • intracerebral hemorrhage • racial differences
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