This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ronkainen, A. Articles by Hernesniemi, J. Search for Related Content PubMed PubMed Citation Articles by Ronkainen, A. Articles by Hernesniemi, J. Related Collections Health policy and outcome research Acute Cerebral Hemorrhage Primary and Secondary Stroke Prevention Aneurysm, AVM, hematoma

(Stroke. 1999;30:1099-1102.)
© 1999 American Heart Association, Inc.

Original Contributions

Familial Subarachnoid Hemorrhage

Outcome Study

Antti Ronkainen, MD, PhD; Minna Niskanen, MD, PhD; Riitta Piironen, MD Juha Hernesniemi, MD, PhD

From the Departments of Neurosurgery (A.R.) and Anesthesiology and Intensive Care (M.N.), University Hospital of Kuopio (R.P.), Kuopio, Finland, and the Department of Neurosurgery, University Hospital of Helsinki (J.H.), Helsinki, Finland.

Correspondence to Antti Ronkainen, Department of Neurosurgery, Kuopio University Hospital, PO Box 1777, FIN-70210, Kuopio, Finland. E-mail antti.ronkainen{at}kuh.fi

Background and Purpose—The aim of our study was to compare outcome and its determinants in familial subarachnoid hemorrhage and in sporadic subarachnoid hemorrhage in a large and well-documented patient population.

Methods—Patients with aneurysmal subarachnoid hemorrhage (SAH) treated at the Department of Neurosurgery, Kuopio University Hospital, from 1977 to 1995 were included. Patients with polycystic kidney disease were excluded. The Glasgow Outcome Scale (GOS) score at 12 months was studied.

Results—There were 120 patients (97 first-, 15 second-, and 8 third-degree family connections) in 96 different families with familial SAH and 1237 patients with sporadic SAH. Age, gender, and admission grade on the Hunt and Hess scale did not differ between these 2 groups. In both groups >80% of patients were in relatively good condition at admission. The outcome was good (GOS score of 1 to 2) in 87 patients (73%) with familial SAH and in 874 patients (71%) with sporadic SAH. Analysis of 20 variables, including presence of coexisting diseases, aneurysm site and size, amount of blood shown on CT scan, intraventricular bleeding, preoperative intracerebral hematoma and hydrocephalus, as well as postoperative bleeding and vasospasm, revealed no significant differences between study groups. The degree of family connection (first-, second-, and third-degree) did not have any statistically important effect on outcome in the familial group in the Finnish study population. In multivariate analysis the knowledge of familial SAH was not an independent prognostic factor.

Conclusions—Admission status, postoperative course, and outcome were similar in the familial and sporadic SAH groups in this Finnish population, in contrast to previous results. Familial SAH may not be a significant risk factor for poor outcome.

Key Words: cerebral aneurysm • family • Finland • outcome • subarachnoid hemorrhage

This article has been cited by other articles:

				K. Inoue, Y. Mineharu, S. Inoue, S. Yamada, F. Matsuda, K. Nozaki, K. Takenaka, N. Hashimoto, and A. Koizumi Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm: A Preliminary Study Circulation, April 25, 2006; 113(16): 2002 - 2010. [Abstract] [Full Text] [PDF]

				A. K. Ozturk, B. V. Nahed, M. Bydon, K. Bilguvar, E. Goksu, G. Bademci, B. Guclu, M. H. Johnson, A. Amar, R. P. Lifton, et al. Molecular Genetic Analysis of Two Large Kindreds With Intracranial Aneurysms Demonstrates Linkage to 11q24-25 and 14q23-31 Stroke, April 1, 2006; 37(4): 1021 - 1027. [Abstract] [Full Text] [PDF]