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(Stroke. 1999;30:1591-1597.)
© 1999 American Heart Association, Inc.
Original Contributions |
Diffusion- and Perfusion-Weighted MRI
The DWI/PWI Mismatch Region in Acute Stroke
From the Department of Neurology (T.N.-H., H.-J.W., M.S., R.J.S., H.-J.F.) and Institute of Diagnostic Radiology (H.-J.W., F.W., U.M.), Heinrich-Heine University, Düsseldorf, Germany, and the Department of Radiology, Stanford University (T.N.-H.), Stanford, Calif.
Correspondence to Dr Tobias Neumann-Haefelin, Department of Radiology, Stanford University, Lucas MRS Center, MC: 5488, Stanford, CA 94305. E-mail tnh{at}s-word.stanford.edu
Background and Purpose—Diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) are relatively new MR techniques increasingly used in acute stroke. During the first hours of stroke evolution, the regions with abnormal perfusion are typically larger than the DWI lesions, and this mismatch region has been suggested to be "tissue at risk." The aim of this study was to evaluate the PWI/DWI mismatch region in acute stroke patients and find parameters indicative of both infarct progression and functional impairment.
Methods—Twenty patients with nonlacunar ischemic stroke
were imaged with DWI, PWI, and conventional MRI within 24 hours of
symptom onset and after 1 week; in addition, the European Stroke Scale
(ESS) score was recorded. With PWI, the volumes of regions with
"time-to-peak" (TTP) delays of 
2, 4, 6, 8, and 10 seconds were
measured; these volumes were compared with the acute DWI lesion
volumes, final infarct size, and ESS score.
Results—In 80% of patients the acute DWI lesion was surrounded
by regions with abnormal TTP delays (PWI>DWI lesion). A TTP delay of
6 s in the mismatch region was found to be associated with lesion
enlargement between the initial and follow-up MRI scans. Lesions
increased in 9 of 12 patients (75%) in whom the area with TTP delay
6 s was larger than the DWI lesion, but they increased in only 1 of 8
(12.5%) of the remaining patients, in whom the area with a TTP delay
6 s was smaller than the DWI lesion. The volume of the regions with
TTP delays of 4 s correlated better with ESS
(r=-0.88, P<0.001) than other PWI (or
DWI) volumes, which indicated that a TTP delay of 
4 s might be the
threshold for functional impairment of brain tissue.
Conclusions—Only patients with severe perfusion deficits in the
PWI/DWI mismatch (TTP delays of 6 s) are at high risk of lesion
enlargement. Functionally, more moderate perfusion deficits (TTP delays
4 and <6 s) appear to also contribute to the acute clinical deficit.
Key Words: diffusion • magnetic resonance imaging • penumbra • perfusion • stroke, acute
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