(Stroke. 2000;31:151.)
© 2000 American Heart Association, Inc.
Original Contributions |
Harmonic Imaging of the Human Brain
Visualization of Brain Perfusion With Ultrasound
From the Department of Neurology, Medical University Lübeck, Lübeck, Germany.
Correspondence to Günter Seidel, MD, Department of Neurology, Medical University at Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. E-mail seidel_g{at}neuro.mu-luebeck.de
Background and Purpose—Through harmonic gray-scale imaging, it is possible to analyze brain tissue perfusion with different ultrasound methods.
Methods—In 12 healthy volunteers, 2 doses (0.5 and 1.5 mL) of Optison, a perfluoropropane-containing contrast agent, were injected intravenously and produced a strong increase of brightness in the brain parenchyma. We used harmonic imaging for quantification of ultrasound intensity in the thalamus, ipsilateral temporoparietal white matter (TPWM), and ipsilateral lateral fissure at both sides. Time-intensity curves were calculated, and peak increase (PI) of intensity and the area under the time-intensity curve (AUC) from baseline were compared.
Results—We found a significant dose dependence of the AUC in all regions at both sides. PI only showed a significant dose dependence in the TPWM but not in the ipsilateral thalamus and lateral fissure. No side differences for AUC and PI were detected in all regions and doses used. We found a significantly higher value of the PI insonating the thalamus from the ipsilateral side compared with the contralateral side. The same result was obtained for the AUC in the left thalamus for both doses and in the right thalamus for the high dose. Using 0.5 mL for insonation of the right thalamus AUC again showed a higher value for the insonation from the ipsilateral compared with the contralateral side but failed to show statistical significance (P=0.08, n=12).
Conclusions—Harmonic gray-scale imaging with Optison showed a strong enhancement effect in the brain parenchyma. A quantitative analysis of perfusion seems difficult because of the depth dependence of the effect. The most robust parameter is the AUC.
Key Words: contrast media • perfluorocarbons • perfusion • ultrasonography
This article has been cited by other articles:
 |
|
 |
|
  E. Bartels and H.-J. Bittermann Transcranial Contrast Imaging of Cerebral Perfusion in Patients With Space-Occupying Intracranial Lesions J. Ultrasound Med., April 1, 2006; 25(4): 499 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Eyding, W. Wilkening, C. Krogias, T. Holscher, H. Przuntek, S. Meves, and T. Postert Validation of the Depletion Kinetic in Semiquantitative Ultrasonographic Cerebral Perfusion Imaging Using 2 Different Techniques of Data Acquisition J. Ultrasound Med., August 1, 2004; 23(8): 1035 - 1040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kern, F. Perren, K. Schoeneberger, A. Gass, M. Hennerici, and S. Meairs Ultrasound Microbubble Destruction Imaging in Acute Middle Cerebral Artery Stroke Stroke, July 1, 2004; 35(7): 1665 - 1670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Eyding, C Krogias, W Wilkening, and T Postert Detection of cerebral perfusion abnormalities in acute stroke using phase inversion harmonic imaging (PIHI): preliminary results J. Neurol. Neurosurg. Psychiatry, June 1, 2004; 75(6): 926 - 929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Seidel, K. Meyer-Wiethe, G. Berdien, D. Hollstein, D. Toth, and T. Aach Ultrasound Perfusion Imaging in Acute Middle Cerebral Artery Infarction Predicts Outcome Stroke, May 1, 2004; 35(5): 1107 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wiesmann, K. Meyer, T. Albers, and G. Seidel Parametric Perfusion Imaging With Contrast-Enhanced Ultrasound in Acute Ischemic Stroke Stroke, February 1, 2004; 35(2): 508 - 513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Meves, W. Wilkening, T. Thies, J. Eyding, T. Holscher, M. Finger, G. Schmid, H. Ermert, and T. Postert Comparison Between Echo Contrast Agent-Specific Imaging Modes and Perfusion-Weighted Magnetic Resonance Imaging for the Assessment of Brain Perfusion Stroke, October 1, 2002; 33(10): 2433 - 2437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. U. Harrer and C. Klotzsch Second Harmonic Imaging of the Human Brain: The Practicability of Coronal Insonation Planes and Alternative Perfusion Parameters Stroke, June 1, 2002; 33(6): 1530 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-J. Rim, H. Leong-Poi, J. R. Lindner, D. Couture, D. Ellegala, H. Mason, M. Durieux, N. F. Kassel, and S. Kaul Quantification of Cerebral Perfusion With "Real-Time" Contrast-Enhanced Ultrasound Circulation, November 20, 2001; 104(21): 2582 - 2587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Federlein, T. Postert, S Meves, S Weber, H Przuntek, and T. Buttner Ultrasonic evaluation of pathological brain perfusion in acute stroke using second harmonic imaging J. Neurol. Neurosurg. Psychiatry, November 1, 2000; 69(5): 616 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wiesmann and G. Seidel Ultrasound Perfusion Imaging of the Human Brain Stroke, October 1, 2000; 31(10): 2421 - 2425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Seidel, C. Algermissen, A. Christoph, T. Katzer, M. Kaps, and R. W. Baumgartner Visualization of Brain Perfusion With Harmonic Gray Scale and Power Doppler Technology : An Animal Pilot Study Editorial Comment: An Animal Pilot Study Stroke, July 1, 2000; 31(7): 1728 - 1734. [Abstract] [Full Text] [PDF]
|
|