(Stroke. 2000;31:404.)
© 2000 American Heart Association, Inc.
Original Contributions |
Influence of Admission Body Temperature on Stroke Mortality
From the Centre for Clinical Epidemiology and Biostatistics, Royal Newcastle Hospital (Y.W., L.L-Y.L., R.F.H., J.F.), and Department of Neurology, John Hunter Hospital (C.L.), New South Wales, Australia.
Correspondence to Yang Wang, MD, Centre for Clinical Epidemiology and Biostatistics, David Maddison Clinical Sciences Building, Royal Newcastle Hospital, Newcastle, New South Wales 2300, Australia. E-mail wyang{at}cceb.newcastle.edu.au
Background and Purpose—The influence of body temperature on stroke outcome remains uncertain. The aim of this study was to investigate the prognostic role of admission body temperature on short-term and long-term mortality in a retrospective cohort study of patients with acute stroke.
Methods—A retrospective cohort of 509 patients with acute stroke,
admitted to a tertiary hospital between July 1, 1995, and June 30,
1997, was studied. The relationship between admission body temperature
and mortality both in-hospital and at 1-year mortality was evaluated.
Body temperature on admission was classified as hypothermia
(
36.5°C), normothermia (>36.5°C and 37.5°C), and
hyperthermia (>37.5°C). Logistic regression and proportional hazards
function analysis were performed after adjustment for clinical
predictors of stroke outcome.
Results—In ischemic stoke, mortality was lower among patients with hypothermia and higher among patients with hyperthermia. The odds ratio for in-hospital mortality in hypothermic versus normothermic patients was 0.1 (95% CI, 0.02 to 0.5). The relative risk for 1-year mortality of hyperthermic versus normothermic patients was 3.4 (95% CI, 1.6 to 7.3). A similar but nonsignificant trend for in-hospital mortality was seen among patients with hemorrhagic stroke.
Conclusions—An association between admission body temperature and stroke mortality was noted independent of clinical variables of stroke severity. Hyperthermia was associated with an increase in 1-year mortality. Hypothermia was associated with a reduction in in-hospital mortality.
Key Words: mortality • stroke, acute • temperature
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