(Stroke. 2000;31:493.)
© 2000 American Heart Association, Inc.
Original Contributions |
Association Between Platelet Glycoprotein Ib
Genotype and Ischemic Cerebrovascular Disease
From the Departments of Laboratory Medicine (A.S., M.M., A.O., Y.T., E.T., K.W.), Hematology (M.M., Y.I.), Neurology (D.I., N.T., Y.F.), and Health Center (T.Y., I.S.), School of Medicine, Keio University, Tokyo, and Sankyo Inc (M.Y.), Tokyo, Japan.
Correspondence to Mitsuru Murata, MD, Division of Hematology, Department of Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. E-mail murata{at}mc.med.keio.ac.jp
Background and Purpose—Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD.
Methods—Two hundred patients with ischemic CVD, as
confirmed by brain CT and/or MRI, and 317 age- and sex-matched control
subjects without clinical evidence of CVD or cardiovascular
disease were analyzed for their genotype
frequencies of the 145Thr/Met dimorphism of the 
-chain
of GPIb (GPIb).
Results—Genotypes with 145Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women <60 years of age was 10.6 (95% confidence intervals, 2.2 to 51.7). Although the number of patients studied was small (n=24), transient ischemic attack showed the highest odds ratio (4.3, P=0.0004), followed by lacunar infarction (OR=2.2, P=0.0024) and atherothrombotic infarction (OR=1.5, P=0.3143). Logistic regression analysis revealed that the presence of Met-allele was independently associated with CVD.
Conclusions—Our study suggests that the platelet GPIb
genotype is a genetic risk factor for ischemic CVD.
Key Words: cerebrovascular disorders • genetics • platelets • polymorphism • thrombosis
This article has been cited by other articles:
 |
|
 |
|
  D. C. Herak, M. R. Antolic, J. L. Krleza, M. Pavic, S. Dodig, V. Duranovic, A. B. Brkic, and R. Zadro Inherited Prothrombotic Risk Factors in Children With Stroke, Transient Ischemic Attack, or Migraine Pediatrics, April 1, 2009; 123(4): e653 - e660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Maguire, A. Thakkinstian, J. Sturm, C. Levi, L. Lincz, M. Parsons, S. Whyte, and J. Attia Polymorphisms in Platelet Glycoprotein 1b{alpha} and Factor VII and Risk of Ischemic Stroke: A Meta-Analysis Stroke, June 1, 2008; 39(6): 1710 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Corsetti, D. Ryan, A. J. Moss, D. L. Rainwater, W. Zareba, and C. E. Sparks Glycoprotein Ib{alpha} Polymorphism T145M, Elevated Lipoprotein-Associated Phospholipase A2, and Hypertriglyceridemia Predict Risk for Recurrent Coronary Events in Diabetic Postinfarction Patients Diabetes, May 1, 2007; 56(5): 1429 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Feinbloom and K. A. Bauer Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events Arterioscler Thromb Vasc Biol, October 1, 2005; 25(10): 2043 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tsiara, M. Elisaf, I. A. Jagroop, and D. P. Mikhailidis Platelets as Predictors of Vascular Risk: Is There a Practical Index of Platelet Activity? Clinical and Applied Thrombosis/Hemostasis, July 1, 2003; 9(3): 177 - 190. [Abstract] [PDF]
|
|
|
|
|
|
H. Ulrichts, K. Vanhoorelbeke, S. Cauwenberghs, S. Vauterin, H. Kroll, S. Santoso, and H. Deckmyn Von Willebrand Factor But Not {alpha}-Thrombin Binding to Platelet Glycoprotein Ib{alpha} Is Influenced by the HPA-2 Polymorphism Arterioscler Thromb Vasc Biol, July 1, 2003; 23(7): 1302 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Meschia Addressing the Heterogeneity of the Ischemic Stroke Phenotype in Human Genetics Research Stroke, December 1, 2002; 33(12): 2770 - 2774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Ito, N Tanahashi, M Murata, H Sato, I Saito, K Watanabe, and Y Fukuuchi Notch3 gene polymorphism and ischaemic cerebrovascular disease J. Neurol. Neurosurg. Psychiatry, March 1, 2002; 72(3): 382 - 384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bak, D. Gaist, S. H. Sindrup, A. Skytthe, and K. Christensen Genetic Liability in Stroke: A Long-Term Follow-Up Study of Danish Twins Stroke, March 1, 2002; 33(3): 769 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Kunicki The Influence of Platelet Collagen Receptor Polymorphisms in Hemostasis and Thrombotic Disease Arterioscler Thromb Vasc Biol, January 1, 2002; 22(1): 14 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.Y. Streifler, N. Rosenberg, A. Chetrit, R. Eskaraev, B.A. Sela, R. Dardik, A. Zivelin, B. Ravid, J. Davidson, U. Seligsohn, et al. Cerebrovascular Events in Patients With Significant Stenosis of the Carotid Artery Are Associated With Hyperhomocysteinemia and Platelet Antigen-1 (Leu33Pro) Polymorphism Stroke, December 1, 2001; 32(12): 2753 - 2758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Kandzari and P. J. Goldschmidt-Clermont Platelet polymorphisms and ischemic heart disease: moving beyond traditional risk factors J. Am. Coll. Cardiol., October 1, 2001; 38(4): 1028 - 1032. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mikkelsson, M. Perola, A. Penttila, and P. J. Karhunen Platelet Glycoprotein Ib{alpha} HPA-2 Met/VNTR B Haplotype as a Genetic Predictor of Myocardial Infarction and Sudden Cardiac Death Circulation, August 21, 2001; 104(8): 876 - 880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Baker, J. Eikelboom, E. Lofthouse, N. Staples, V. Afshar-Kharghan, J. A. Lopez, Y. Shen, M. C. Berndt, and G. Hankey Platelet glycoprotein Ib{alpha} Kozak polymorphism is associated with an increased risk of ischemic stroke Blood, July 1, 2001; 98(1): 36 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Williams and P. F. Bray Genetics of Arterial Prothrombotic Risk States Exp Biol Med, May 1, 2001; 226(5): 409 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Frank, A. P. Reiner, S. M. Schwartz, P. N. Kumar, R. M. Pearce, P. G. Arbogast, W. T. Longstreth Jr, F. R. Rosendaal, B. M. Psaty, and D. S. Siscovick The Kozak sequence polymorphism of platelet glycoprotein Ib{alpha} and risk of nonfatal myocardial infarction and nonfatal stroke in young women Blood, February 15, 2001; 97(4): 875 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ito, M. Murata, N. Tanahashi, H. Sato, A. Sonoda, I. Saito, K. Watanabe, and Y. Fukuuchi Polymorphism in the Promoter of Lipopolysaccharide Receptor CD14 and Ischemic Cerebrovascular Disease Stroke, November 1, 2000; 31(11): 2661 - 2664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Reiner, P. N. Kumar, S. M. Schwartz, W. T. Longstreth Jr, R. M. Pearce, F. R. Rosendaal, B. M. Psaty, and D. S. Siscovick Genetic Variants of Platelet Glycoprotein Receptors and Risk of Stroke in Young Women Stroke, July 1, 2000; 31(7): 1628 - 1633. [Abstract] [Full Text] [PDF]
|
|