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(Stroke. 2000;31:892.)
© 2000 American Heart Association, Inc.

Original Contributions

Transient Focal Neurological Deficits During Pregnancy in Carriers of Inherited Thrombophilia

Michael J. Kupferminc, MD; Daniel Yair, MD; Natan M. Bornstein, MD; Joseph B. Lessing, MD Amiram Eldor, MD

From the Department of Obstetrics and Gynecology, Lis Maternity Hospital (M.J.F., D.Y., J.B.L.), and the Department of Hematology (A.E.) and Stroke Unit of the Department of Neurology (N.M.B.), Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Correspondence to M.J. Kupferminc, MD, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel. E-mail tmcobgyn{at}tasmc.health.gov.il

Background and Purpose—The aim of our study was to investigate the association of transient ischemic cerebrovascular events during pregnancy and inherited thrombophilias.

Methods—The study group comprised previously healthy pregnant women who had their first ischemic event during pregnancy (n=12). The control group included 24 healthy women matched with the study women for age, ethnicity, and smoking status. All women were evaluated for factor V Leiden mutation, methylenetetrahydrofolate reductase C677T gene mutation, the G20210A mutation in the prothrombin gene, and deficiencies of plasma proteins C and S and antithrombin III.

Results—Inherited thrombophilia was detected in 83% of women with transient neurological manifestations compared with 17% of the control group (P<0.001).

Conclusions—Transient cerebrovascular ischemic events during pregnancy are associated with a high rate of inherited thrombophilias. Pregnant women with focal neurological symptoms should be evaluated for thrombophilia.

Key Words: cerebrovascular disorders • thrombophilia • pregnancy • stroke, acute

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				A. Liberman, D. Karussis, T. Ben-Hur, O. Abramsky, and R. R. Leker Natural Course and Pathogenesis of Transient Focal Neurologic Symptoms During Pregnancy Arch Neurol, February 1, 2008; 65(2): 218 - 220. [Abstract] [Full Text] [PDF]